96335-42-1

Basic information

• Product Name: Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 5-amino- (9CI)
• Synonyms: Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 5-amino- (9CI)
• CAS NO: 96335-42-1
• Molecular Formula: C6H6N4O
• Molecular Weight: 150.13804
• Product Categories: AMINEPRIMARY
• Mol File: 96335-42-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 5-amino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 5-amino- (9CI)(96335-42-1)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 5-amino- (9CI)(96335-42-1)

Safety Data

• Hazardous Substances Data: 96335-42-1(Hazardous Substances Data)

Upstream product

• 27317-59-5 Ethyl 3-ethoxy-3-iminopropionate 
• 1225387-53-0 3⁽⁵⁾-aminopyrazole 
• 41680-34-6 5-amino-1H-pyrazole-4-carboxylic acid 
• 2318-25-4 ethyl 3-ethoxy-3-iminopropanoate hydrochloride 

Downstream Products

• 1190058-38-8 1-(5-(4-(2-hydroxypropan-2-yl)benzamido)pyrazolo[1,5-a]pyrimidin-7-yl)-N-isopropylpiperidine-4-carboxamide 
• 1190058-39-9 (R)-1-(5-(4-(2-hydroxypropan-2-yl)benzamido)pyrazolo[1,5-a]pyrimidin-7-yl)-N-methylpiperidine-3-carboxamide 
• 1190058-34-4 4-(2-hydroxypropan-2-yl)-N-(7-(4-(trifluoromethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)benzamide 
• 1190045-91-0 4-(2-hydroxypropan-2-yl)-N-(7-(4-(2-hydroxypropan-2-yl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)benzamide 
• 1190058-37-7 1-(5-(4-(2-hydroxypropan-2-yl)benzamido)pyrazolo[1,5-a]pyrimidin-7-yl)-N-methylpiperidine-4-carboxamide 
• 1190057-99-8 N-(7-(4-(1-hydroxy-2-methylpropyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide 
• 1190058-01-5 N-(7-(4-acetyl-1,4-diazepan-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide 
• 1190058-12-8 methyl 1-(5-(4-(2-hydroxypropan-2-yl)benzamido)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-4-carboxylate 
• 1190045-90-9 4-(2-hydroxypropan-2-yl)-N-(7-(4-(methoxymethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)benzamide 
• 1190058-00-4 N-(7-(4-formyl-1,4-diazepan-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide 
• 1190058-33-3 N-(7-(4,4-difluoropiperidin-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-(2-hydroxypropan-2-yl)benzamide 

Relevant articles and documents

Synthesis of 5-aminopyrazolo[1,5-a]pyrimidine-7(4H)-ones

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BIARYL KINASE INHIBITORS

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS

The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I) wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture