96356-15-9

Basic information

• Product Name: ethyl 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carboxylate
• Synonyms: ethyl 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carboxylate
• CAS NO: 96356-15-9
• Molecular Formula: C₉H₁₁N₃O₂S
• Molecular Weight: 225.26754
• Mol File: 96356-15-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 120 °C(Solv: water (7732-18-5))
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• PKA: 0.97±0.50(Predicted)
• CAS DataBase Reference: ethyl 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carboxylate(96356-15-9)
• EPA Substance Registry System: ethyl 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carboxylate(96356-15-9)

Safety Data

• Hazardous Substances Data: 96356-15-9(Hazardous Substances Data)

Upstream product

• 108-33-8 5-methyl-1,3,4-thiadiazol-2-amine 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Relevant articles and documents

Synthesis and anticancer evaluation of some new hydrazone derivatives of 2,6-dimethylimidazo[2,1-b][1,3,4]thiadiazole-5-carbohydrazide

In this study, some novel 2,6-dimethyl-N′-substituted phenylmethylene-imidazo[2,1-b][1,3,4]thiadiazole-5-carbohydrazides (3a-3h) were synthesized from 2,6-dimethylimidazo-[2,1-b][1,3,4]thiadiazole-5-carbohydrazide (2). The newly synthesized compounds (3a-3h) were evaluated in the National Cancer Institute's 3-cell line, one dose in vitro primary cytotoxicity assay. Compounds 3c and 3h which passed the criteria for activity in this assay (20-29% growth percentages) were scheduled automatically for evaluation against the full panel of 60 human tumor cell lines at a minimum of five concentrations at 10-fold dilutions. Sulforhodamine B (SRB) protein assay was used to estimate cell stability or growth. 2,6-Dimethyl-N′-(2-hydroxyphenylmethylidene)imidazo[2,1-b][1,3,4] thiadiazole-5-carbohydrazide (3c) showed the most favorable cytotoxicity. This compound demonstrated the most marked effects in the National Cancer Institute's 60 human tumor cell line in vitro screen on an ovarian cancer cell line (OVCAR log10GI50 value -5.51).