96360-08-6Relevant academic research and scientific papers
De novo asymmetric syntheses of muricatacin and its analogues via dihydroxylation of dienoates
Ahmed, Md. Moinuddin,Cui, Hu,O'Doherty, George A.
, p. 6686 - 6689 (2007/10/03)
A short and highly efficient route to both enantiomers of muricatacin as well as the C-5-epimer has been developed. The key to the overall transformation is the highly regio- and enantioselective Sharpless asymmetric dihydroxylation of an (E,Z)-dienoate. The highly efficient stereoselective synthesis prepares (-)-muricatacin in seven steps and 66% overall yield.
