96367-00-9Relevant academic research and scientific papers
Stereoselective construction of Bi-spirooxindole frameworks via a Michael addition/cyclization and an unexpected redox/oxidative coupling/cyclization
Zhu, Xiao-Qian,Wu, Jia-Shou,Xie, Jian-Wu
, p. 8327 - 8334 (2016)
A series of polyheterocyclic bi-spirooxindole derivatives with skeletal diversity and molecular complexity were prepared via a cascade synthesis strategy. The key step transfer hydrogenation is smoothly fulfilled by using 3-hydroxyoxindole derivatives as the hydrogen source and the oxidative coupling happened by using simple and green molecular oxygen as the oxidant. The plausible mechanisms for the unexpected redox/oxidative coupling/cyclization were also given.
Iron catalyzed efficient synthesis of poly-functional primary amines via the direct use of ammonia
Ma, Chaoqun,Chen, Jianghui,Xing, Dong,Sheng, Yuan,Hu, Wenhao
supporting information, p. 2854 - 2857 (2017/03/11)
An iron catalyzed three-component reaction of alkyl diazoesters, isatins and ammonia is reported. This reaction provided convenient access to non-protected β-hydroxy-α-aminoesters with adjacent quaternary stereocenters. This transformation is achieved via trapping of ammonium ylide which is generated from a diazocompound and ammonia under mild reaction conditions. Poly-functional group unprotected amines are obtained exclusively with up to 77% yield and 62?:?38 dr.
