96385-23-8

Usage

Uses

Used in Organic Synthesis:
P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate is used as a reagent for the formation of carbon-carbon bonds and other organic transformations, playing a crucial role in various organic synthesis processes.
Used in Catalysis Reactions:
This phosphonium salt is utilized as a catalyst in a range of chemical processes, enhancing the efficiency and selectivity of reactions, particularly those involving the formation of carbon-carbon bonds.
Used in Specific Synthetic Methodologies:
The fluorine-containing groups in P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate confer unique properties and reactivity, making it useful in specialized synthetic methodologies that require such characteristics.

Upstream product

• 603-35-0 triphenylphosphine 
• 88410-12-2 [Fluoro-(triphenyl-λ⁵-phosphanylidene)-methyl]-triphenyl-phosphonium; bromide 

Downstream Products

• 351-78-0 β-fluorostyrene 
• 444334-14-9 (E)-1-[(dimethylamino)methyl]-2-fluoromethylidenecyclohexane 
• 80474-14-2 flixotide 
• 28096-33-5 Triphenylphosphoniumfluormethylid 

Relevant academic research and scientific papers

Allylamine derivative as well as preparation method and application thereof

The invention relates to an allylamine derivative as well as a preparation method and application thereof, and in particular, relates to a compound represented by a formula I, or a stereoisomer, a tautomer, a polymorphic substance, a solvate, an N-oxide, an isotope labeled compound, a metabolite, a prodrug or ester thereof, or a pharmaceutically acceptable salt thereof. The compound has a higher inhibitory activity against vascular adhesion protein 1/semicarbazide sensitive amine oxidase, a good selectivity against monoamine oxidase and diamine oxidase; and additionally, in some embodiments, the mixture has a high in vivo bioavailability as well as safety.

FLUOROALLYLAMINE DERIVATIVE AND USE THEREOF

The present invention relates to a fluoroallylamine derivative and use thereof. In particular, the present invention relates to a compound as shown in Formula I, a prodrug, an isomer, an isotope-labeled compound, a solvate or a pharmaceutically acceptable salt thereof, which has VAP-1/SSAO inhibitory activity, and can be used for treating a disease associated with VAP-1/SSAO overactivity.

VASCULAR ADHESION PROTEIN-1 (VAP-1) MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.

SSAO INHIBITOR

The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.

Halogenated allyl amine type SSAO/VAP-1 inhibitor and application thereof

The invention belongs to the technical field of medicine, and particularly relates to a halogenated allyl amine type compound shown as a formula I, medically acceptable salt, ester or stereo isomers thereof, wherein R1, R2, R3, R4, R5, R6, L1, Cy1, R7 and p are defined in description. The invention also relates to a medicine preparation containing the compounds, a medicine composition containing the compounds, and application of the compounds to prevention and/or treatment on diseases relevant to SSAO/VAP 1 protein or diseases caused by SSAO/VAP 1 protein mediating. The formula I is shown in the description.

Direct electrophilic monofluoromethylation

Monofluoromethyl derivatives of various nucleophiles have been synthesized using a new electrophilic monofluoromethylating reagent developed. The S-(monofluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic monofluoromethyl group into C, S, O, N, and P nucleophiles. This methodology has been expanded for the synthesis of various biologically important compounds.