96449-70-6

Upstream product

• 617-52-7 Dimethyl itakonate 
• 2393-23-9 4-methoxy-benzylamine 
• 149505-71-5 methyl 1-[(4-methoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylate 

Downstream Products

• 208124-73-6 (S)-4-Iodomethyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one 
• 1019650-93-1 1-(4-methoxybenzyl)-4-(phenoxymethyl)pyrrolidin-2-one 
• 1019650-94-2 4-(phenoxymethyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

GSK-3BETA INHIBITOR

For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.

IMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to imidazole derivatives of the formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Mono-and disubstituted 3-propyl gamma-aminobutyric acids

The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I 1The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.

Method of treating tinnitus

The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

Method of treating cartilage damage

The invention relates to a method of preventing or treating cartilage damage by administering a GABA analog such as, for example, a compound of Formula 1and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

Cyclic imino derivatives and pharmaceutical compositions containing them

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.

1-substituted-4-hydroxymethyl-pyrrolidin-2-ones

Compounds of the formula STR1 wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms; and R2 is pyridyl, phenyl or mono-, di- or tri-substituted phenyl, where the substituents are alkyl of 1 to 2 carbon atoms, alkoxy of 1 to 2 carbon