96450-20-3

Upstream product

• 95-21-6 2-methyl-1,3-benzoxazole 
• 98-95-3 nitrobenzene 
• 41014-43-1 2-(chloromethyl)benzoxazole 
• 90298-66-1 Benzooxazole-2-carbodithioic acid methyl ester 
• 62-53-3 aniline 

Downstream Products

• 109792-13-4 2-(5-Chloromethyl-4-phenyl-4H-[1,2,4]triazol-3-yl)-benzooxazole 
• 115924-87-3 C₁₄H₁₂N₄O 

Relevant academic research and scientific papers

Functionalization of primary ch bonds in picolines toward pyridylthioamides

We report a method for coupling of nitroarenes, 2- or 4-methylazaarenes, and elemental sulfur to afford (2-pyridyl)aryl thioamides. Good tolerance of functionalities was observed, including primary and secondary amines, bromo, iodo, ester, and boronic est

Dithiocarboxylic Acids, Dithiocarboxylic Esters, or Thiocarboxylic Amides by Reaction of Methylene-active Chloromethyl Compounds with Sulfur

With a mixture of sulfur and amine in DMF at room temperature halomethyl compounds (1,5-10) can be oxidized to give thiocarboxylic acids (2,11-16) and their derivatives (3,4,17-35).We studied this reaction in detail especially with chloroacetic derivatives (11-15) or chloromethyl heterocycles (16) formally derived from chloroacetic acid.The resulting thiooxalic acid derivatives (11-27) represent activated acids and very useful C2-synthons, especially for the synthesis of heterocycles.Oxidation in the presence of triethylamine leads to dithiocarboxylates (11-16) which can be alkylated to dithioesters (17-27) in high yields.As a rule, with different primary and secondary amines instead of tertiary amines these dithiocarboxylates or dithiocarboxylic esters can be transformed already at low temperatures to thioamides (28-35).