96487-85-3 Usage
Description
Norethindrone-3-ethyldienolether, also known as Norethindrone 3-Ethyl Ether, is a derivative of Norethindrone (N676000). It is a synthetic steroid hormone that belongs to the progestin class, which are structurally similar to progesterone and have various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Norethindrone-3-ethyldienolether is used as a pharmaceutical ingredient for the development of contraceptives and hormone replacement therapies. It helps regulate menstrual cycles, prevents ovulation, and provides relief from symptoms associated with hormonal imbalances.
Used in Contraceptives:
Norethindrone-3-ethyldienolether is used as an active ingredient in combined oral contraceptives, where it works synergistically with estrogen to prevent pregnancy. It inhibits ovulation, thickens cervical mucus to prevent sperm penetration, and alters the endometrial lining to reduce the chances of implantation.
Used in Hormone Replacement Therapy (HRT):
Norethindrone-3-ethyldienolether is used as a component in hormone replacement therapy to alleviate symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. It helps restore hormonal balance and reduce the risk of osteoporosis in postmenopausal women.
Used in Treatment of Endometriosis:
Norethindrone-3-ethyldienolether is used as a therapeutic agent for the treatment of endometriosis, a condition where the endometrial tissue grows outside the uterus. It helps reduce inflammation, pain, and the growth of endometrial tissue, improving the quality of life for affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 96487-85-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,4,8 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 96487-85:
(7*9)+(6*6)+(5*4)+(4*8)+(3*7)+(2*8)+(1*5)=193
193 % 10 = 3
So 96487-85-3 is a valid CAS Registry Number.
96487-85-3Relevant articles and documents
Preparation method of norethindrone acetate (by machine translation)
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Paragraph 0008; 0034; 0036, (2020/11/23)
The invention discloses a preparation method of norethindrone acetate and belongs to the technical field of drug preparation and processing. The method uses 19 - demethyl -4 - androstenedione as a starting raw material, protects, acetylenically, hydrolyses and esterifies 4 steps to prepare the norethindrone acetate. To the preparation method of the norethindrone acetate, the defects of a traditional process are overcome, reaction conditions are mild, impurities are reduced, overall conversion rate is high, operation is simple and convenient, and the method is suitable for industrial production and has a wide market prospect. (by machine translation)
Doping in sport-2. Quantification of the impurity 19-norandrostenedione in pharmaceutical preparations of norethisterone
Walker, Christopher J.,Cowan, David A.,James, Vivian H.T.,Lau, Joanne C.Y.,Kicman, Andrew T.
scheme or table, p. 335 - 340 (2009/06/08)
The finding of measurable amounts of 19-norandrostenedione in norethisterone tablets prompted us to develop an assay to quantify this steroid. 19-Norandrostenedione is an anabolic steroid whose use in sport is prohibited by the World Anti-Doping Agency (WADA). The assay was developed using isotope dilution and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the quantification of 19-norandrostenedione in norethisterone formulations, with [3,4-13C2]-19-norandrostenedione as the internal standard. The results showed amounts up to 1.01 ± 0.01 μg (mean ± S.E.M.) per tablet in those containing 5 mg of norethisterone or norethisterone acetate (0.02%, w/w) and up to 0.5 ± 0.01 μg (mean ± S.E.M.) per tablet (0.05%, w/w) in oral contraceptive tablets containing 0.35-1.5 mg of norethisterone or norethisterone acetate. No tablet tested exceeded the British Pharmacopoeia limit of 0.1% for this impurity.
