965-90-2 Usage
Uses
Used in Livestock Industry:
Ethylestrenol is used as an illegal growth promoter in livestock for its ability to enhance muscle growth and weight gain in animals. However, its use is prohibited due to potential health risks and is often tested for as part of a routine screening program for forbidden growth promoters.
Originator
Maxibolin,Organon,US,1964
Manufacturing Process
4.5 grams of lithium cut to small pieces are added to 435 ml of dry
ethylamine which is cooled in ice. After the solution turns blue 9 grams of
17α-ethyloestradiol-3-ethylether dissolved in 900 ml of dry ether are added.
Subsequently, the reaction mixture is stirred at a temperature of 0° to 5°C for
20 hours, after which 50 ml of absolute ethanol are added. Then the
ethylamine is distilled off at low pressure. To the remaining solution 50 ml of
ether and 50 ml of water are added. The water layer is separated and
extracted a few times with ether. The collected ether extracts are added to the
ethereal layer, after which this ethereal solution is washed with a 2 N
hydrochloric acid solution, subsequently with a saturated sodium bicarbonate
solution, and then with water. The ethereal solution is then dried on sodium
sulfate and finally evaporated to dryness.
The crude product is distributed between equal parts of petroleum ether and
70% methanol. From the petroleum ether layer 5.6 grams of Δ4-17α-ethyl-
17β-hydroxy-19-norandrostenewith a melting point of about 50°C are
obtained.
Therapeutic Function
Anticoagulant
World Health Organization (WHO)
Ethylestrenol, an anabolic steroid, was introduced in 1964. In 1982, low dosage preparations were prohibited in Bangladesh due to inadmissible
promotion of products containing anabolic steroids for malnourished children.
Higher dosage preparations of ethylestrenol remain available in many countries,
including Bangladesh, for several highly specific but limited indications that apply
to patients with chronic debilitating and emaciating diseases, particularly
associated with neoplasia and some types of aplastic anaemia. Ethylestrenol is
additionally used for its fibrinolytic activity.
Check Digit Verification of cas no
The CAS Registry Mumber 965-90-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,6 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 965-90:
(5*9)+(4*6)+(3*5)+(2*9)+(1*0)=102
102 % 10 = 2
So 965-90-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h6,15-18,21H,3-5,7-13H2,1-2H3/t15-,16+,17+,18-,19-,20-/m0/s1
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