96515-79-6

Usage

InChI:InChI=1/C7H4ClFO/c8-6-1-2-7(9)5(3-6)4-10/h1-4H

Upstream product

• 452-66-4 5-chloro-2-fluorotoluene 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 394-30-9 5-chloro-2-fluorobenzoic acid 
• 768-66-1 2,2,6,6-tetramethyl-piperidine 

Downstream Products

• 886586-51-2 5-chloro-2-(4-chloro-2-methoxy-phenoxy)-benzaldehyde 
• 1310531-89-5 5-chloro-2-(3-methylpyrazol-1-yl)benzaldehyde 
• 1310530-46-1 5-{1-tert-butyl-2-[5-chloro-2-(3-methylpyrazol-1-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine 
• 1310532-07-0 5-chloro-2-(5-methyl-1H-1,2,4-triazol-1-yl)benzaldehyde 
• 1310532-06-9 5-chloro-2-(3-methyl-1H-1,2,4-triazol-1-yl)benzaldehyde 
• 1310530-58-5 5-{1-tert-butyl-2-[5-chloro-2-(5-methyl-1,2,4-triazol-1-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine 
• 1310530-57-4 5-{1-tert-butyl-2-[5-chloro-2-(3-methyl-1,2,4-triazol-1-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine 
• 1310532-08-1 5-(2-aminopyrimidin-5-yl)-1-tert-butyl-2-[5-chloro-2-(3-methyl-1,2,4-triazol-1-yl)phenyl]-2,3-dihydro-1H-benzimidazol-2-ol 
• 1310532-09-2 5-(2-aminopyrimidin-5-yl)-1-tert-butyl-2-[5-chloro-2-(5-methyl-1,2,4-triazol-1-yl)phenyl]-2,3-dihydro-1H-benzimidazol-2-ol 
• 1332593-91-5 (R)-1-(5-chloro-2-fluorophenyl)ethan-1-amine hydrochloride 

Relevant academic research and scientific papers

ALK5 INHIBITORS

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

ANTIDIABETIC SPIROCHROMAN COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

Treatment of asthma with MEK inhibitors

This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II:

Combination chemotherapy

Mitotic inhibitors such as paclitaxel have improved antitumor activity when used in combination with a selective MEK inhibitor, especially a phenyl amine compound of Formula I and II:

Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof

The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally sub

2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors

Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6are hydrogen or substituent groups such as alkyl, and where R7

Method of treating or preventing septic shock by administering a MEK inhibitor

The present invention provides a method for treating or preventing septic shock. Specifically, the present invention provides a method of treating or preventing septic shock by administering to a patient a MEK inhibitor.

Heterocyclic pesticidal compounds

Compounds of the formula (I) STR1 which contain between 10 and 27 carbon atoms, and wherein m and n are independently selected from 0, 1 and 2; R2a is hydrogen, methyl, or ethyl; R2b is acetylene or contains between 3 and 18 carbon atoms and is a group R7, wherein R7 is a C1-13 non-aromatic hydrocarbyl group, optionally substituted by a cyano or C1-4 carbalkoxy group and/or by one or two hydroxy groups and/or by one to five halo atoms which are the same or different and/or by one to three groups R8 which are the same or different and each contain one to four hetero atoms, which are the same or different and are chosen from oxygen, sulphur, nitrogen and silicon, 1 to 10 carbon atoms and optionally 1 to 6 fluoro or chloro atoms or R2b is a 6-membered aromatic ring substituted by cyano and/or by one to three groups R8 and/or by a group --C CH, --C C-R7 or C C-halo and/or by one to five halo atoms and/or by one to three C1-4 haloalkyl groups wherein R7 and R8 are as hereinbefore defined; R4 and R6 are the same or different and are chosen from hydrogen, methyl, trifluoromethyl or cyano; and R5 is hydrogen or methyl provided that R2b is not propyl or butyl are described which have pesticidal activity, particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (I), their use in the control of pests and method for their preparation are also disclosed.

Synthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: Highly potent and long-lasting calcium antagonists

New 1,4-dihydropyridine derivatives bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2,2-dimethylpropyl ester were synthesized and their antihypertensive activities were examined in normotensive rats and spontaneously hypertensi