96546-95-1

Basic information

• Product Name: 5-{[(2-ethylquinazolin-4-yl)oxy]methyl}-3-[(4-phenylpiperazin-1-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione
• CAS NO: 96546-95-1
• Molecular Formula: C₂₄H₂₆N₆O₂S
• Molecular Weight: 462.5672
• Mol File: 96546-95-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 565.2°C at 760 mmHg
• Flash Point: 295.6°C
• Density: 1.34g/cm³
• Vapor Pressure: 8.51E-13mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 5-{[(2-ethylquinazolin-4-yl)oxy]methyl}-3-[(4-phenylpiperazin-1-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{[(2-ethylquinazolin-4-yl)oxy]methyl}-3-[(4-phenylpiperazin-1-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione(96546-95-1)
• EPA Substance Registry System: 5-{[(2-ethylquinazolin-4-yl)oxy]methyl}-3-[(4-phenylpiperazin-1-yl)methyl]-1,3,4-oxadiazole-2(3H)-thione(96546-95-1)

Safety Data

• Hazardous Substances Data: 96546-95-1(Hazardous Substances Data)

Upstream product

• 88624-86-6 (2-Ethyl-quinazolin-4-yloxy)-acetic acid ethyl ester 
• 88624-88-8 (2-Ethyl-quinazolin-4-yloxy)-acetic acid hydrazide 
• 3137-64-2 2-Ethyl-quinazolin-4-ol 

Relevant articles and documents

Synthesis of Some Newer Quinazolinyl-oxadiazoles, Thiosemicarbazides and Thiadiazoles as Pharmacologically Active Agents

Fifteen new 3-N,N-dialkylaminomethyl-5-(2-alkyl-1,3-quinazolin-4-yloxymethyl)-2-thio-1,3,4-oxadiazoles (Va-o) have been synthesised by Mannich reaction on 5-(2-alkyl-1,3-quinazolin-4-yloxymethyl)-2-thio-1,3,4-oxadiazoles (IVa-c) with different dialkyl amines.N1-(2-Alkyl-1,3-quinazolin-4-yloxymethylcarbonyl)-N4-(p-substituted-phenyl)thiosemicarbazides (VIa-l) have been prepared by condensing (2-alkyl-1,3-quinazolin-4-oxy)acetic acid hydrazides (III) with p-substituted phenyl isothiocyanates.The thiosemicarbazides (VI) undergo cyclisation in AR H2SO4 to furnish 4-(2- alkyl-1,3-quinazolin-4-yloxymethyl)-2-(p-substituted phenylamino)-1,3,4-thiadiazoles (VIIa-l).Compounds V have been found to be nontoxic and CNS stimulants.Most of them show significant protection against carrageenin-induced inflammation.In the anthelmintic activity screening, compounds VI show 21.8-57.4percent clearance of N. brasiliensis, whereas compounds VI and VII are inactive against H. nana.