96546-97-3

Basic information

• Product Name: 3-(morpholin-4-ylmethyl)-5-{[(2-propylquinazolin-4-yl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione
• CAS NO: 96546-97-3
• Molecular Formula: C₁₉H₂₃N₅O₃S
• Molecular Weight: 401.4826
• Mol File: 96546-97-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 488.4°C at 760 mmHg
• Flash Point: 249.2°C
• Density: 1.39g/cm³
• Vapor Pressure: 1.09E-09mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: 3-(morpholin-4-ylmethyl)-5-{[(2-propylquinazolin-4-yl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(morpholin-4-ylmethyl)-5-{[(2-propylquinazolin-4-yl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione(96546-97-3)
• EPA Substance Registry System: 3-(morpholin-4-ylmethyl)-5-{[(2-propylquinazolin-4-yl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione(96546-97-3)

Safety Data

• Hazardous Substances Data: 96546-97-3(Hazardous Substances Data)

Upstream product

• 4765-54-2 2-propyl-3H-quinazolin-4-one 
• 96547-97-6 (2-Propyl-quinazolin-4-yloxy)-acetic acid hydrazide 
• 84312-79-8 4-Ethoxycarbonylmethoxy-2-n-propylquinazoline 
• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 96547-99-8 5-(2-Propyl-quinazolin-4-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione 

Relevant articles and documents

Synthesis of Some Newer Quinazolinyl-oxadiazoles, Thiosemicarbazides and Thiadiazoles as Pharmacologically Active Agents

Fifteen new 3-N,N-dialkylaminomethyl-5-(2-alkyl-1,3-quinazolin-4-yloxymethyl)-2-thio-1,3,4-oxadiazoles (Va-o) have been synthesised by Mannich reaction on 5-(2-alkyl-1,3-quinazolin-4-yloxymethyl)-2-thio-1,3,4-oxadiazoles (IVa-c) with different dialkyl amines.N1-(2-Alkyl-1,3-quinazolin-4-yloxymethylcarbonyl)-N4-(p-substituted-phenyl)thiosemicarbazides (VIa-l) have been prepared by condensing (2-alkyl-1,3-quinazolin-4-oxy)acetic acid hydrazides (III) with p-substituted phenyl isothiocyanates.The thiosemicarbazides (VI) undergo cyclisation in AR H2SO4 to furnish 4-(2- alkyl-1,3-quinazolin-4-yloxymethyl)-2-(p-substituted phenylamino)-1,3,4-thiadiazoles (VIIa-l).Compounds V have been found to be nontoxic and CNS stimulants.Most of them show significant protection against carrageenin-induced inflammation.In the anthelmintic activity screening, compounds VI show 21.8-57.4percent clearance of N. brasiliensis, whereas compounds VI and VII are inactive against H. nana.