96574-01-5

Basic information

• Product Name: Salvianolic acid
• Synonyms: (2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid;SALVIANOLIC ACID A 98.0% BY HPLC;Danphenolic acid A;(R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)o;Salvianolic acid A, froM Salvia Miltiorrhiza;(R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)oxy)propanoic acid;(αR)-α-[[(2E)-3-[2-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid;Dan phenolic acid A hydrate
• CAS NO: 96574-01-5
• Molecular Formula: C26H22O10
• Molecular Weight: 494.45
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 96574-01-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 164-167°C
• Boiling Point: 858.7 °C at 760 mmHg
• Flash Point: 292.9 °C
• Appearance: yellow/
• Density: 1.58 g/cm³
• Vapor Pressure: 2.04E-31mmHg at 25°C
• Refractive Index: 1.789
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: H2O: ≥19mg/mL
• PKA: 2.78±0.10(Predicted)
• BRN: 2660108
• CAS DataBase Reference: Salvianolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Salvianolic acid(96574-01-5)
• EPA Substance Registry System: Salvianolic acid(96574-01-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 96574-01-5(Hazardous Substances Data)

Usage

Description

Salvianolic acid A is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties. It has been reported to reduce leukocyte-endothelial adherence, as well as inhibit inflammation and matrix metalloproteinases, suppress apoptosis, and reduce lipid peroxidation in damaged cardiac tissue.

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 96574-01-5 differently. You can refer to the following data:
1. ISalvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza. Antioxidant activities of Sal A and Sal B were also evaluated the ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC50 values were 1.35 0.00 and 1.43 0.01 .mu.g/mL.
2. ISalvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza. Antioxidant activities of Sal A and Sal B were also evaluated and the ABTS results showed that Sal A and Sal B exhibited high total antioxidant activities, their EC50 values were 1.35 0.00 and 1.43 0.01 .mu.g/mL.

General Description

Salvianolic acid A is a phenolic acid, isolated from Danshen, a traditional Chinese medicine, commonly used for the treatment of bone loss, chronic renal failure, hepatocirrhosis, hepatitis, coronary heart disease and cerebrovascular disease.

Biochem/physiol Actions

Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.

InChI:InChI=1/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+