96610-41-2

Upstream product

• 96626-81-2 1-Benzyl-3-carbethoxy-3,4-dimethyl-4-(3-methoxyphenyl)-6-piperidon 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 80534-78-7 methyl-1 metamethoxybenzylidene cyanoacetate d'ethyle 
• 117822-02-3 1-Cyano-2-(3-methoxyphenyl)-2-methyl-1,3-propandicarbonsaeurediethylester 
• 96610-39-8 3-Carbethoxy-3,4-dimethyl-4-(3-methoxyphenyl)-6-piperidon 
• 100-44-7 benzyl chloride 

Downstream Products

• 96626-49-2 1-[2-(2-Chloro-phenyl)-ethyl]-4-(3-methoxy-phenyl)-3,3,4-trimethyl-piperidine 
• 96626-51-6 3-{1-[2-(2-Chloro-phenyl)-ethyl]-3,3,4-trimethyl-piperidin-4-yl}-phenol 
• 96610-47-8 1-Benzyl-4-(3-methoxyphenyl)-3,3,4-trimethylpiperidin 
• 96626-55-0 4-(3-Methoxy-phenyl)-3,3,4-trimethyl-1-(3-methyl-but-2-enyl)-piperidine 
• 96626-45-8 1-Allyl-4-(3-methoxyphenyl)-3,3,4-trimethylpiperidin 
• 96626-47-0 1-Allyl-4-(3-hydroxyphenyl)-3,3,4-trimethylpiperidin 
• 96610-53-6 4-(3-Methoxy-phenyl)-1,3,3,4-tetramethyl-piperidine 
• 96626-43-6 3-(1,3,3,4-Tetramethyl-piperidin-4-yl)-phenol 
• 96610-50-3 4-(3-Methoxyphenyl)-3,3,4-trimethyl-piperidin 
• 96610-44-5 1-Benzyl-3,4-dimethyl-4-(3-methoxyphenyl)-3-(methylsulfonyloxymethyl)-piperidin 

Relevant academic research and scientific papers

Synthesis and analgesic activity of 1,3,3,4,4-substituted piperidines

A series of 1,3,3,4,4-substituted piperidines has been prepared by a regioselective lithium ethylacetate condensation with cis/trans 2-butenoic or 2-propenoic acid ethylester derivatives, therapy affording the propane dicarboxylic acid diethylesters which were subjected to a number of reactions to give the title compounds. Their analgesic, morphinomimetic and morphine-antagonistic properties were determined. X-ray analysis of the 4-(3-hydroxyphenyl)-piperidine confirmed the undesired equatorial phenyl conformer explaining the possible failure to show biological properties throughout the 4-methyl-4-phenyl series. Although no strong analygesia or morphine-antagonism was found in the 4,4-diphenyl-series either, some of these compounds possess binding affinities to the 3H-naloxone binding site comparable to the reference compound bremazocine and morphine. As of yet we can only speculate why compounds with a high affinity to the receptor neither show analgesia, nor antagonize morphine induced analgesia.