96719-47-0

Usage

Uses

Used in Pharmaceutical Development:
1-(2-bromophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline is used as a potential drug candidate for the treatment of neurological disorders due to its pharmacological properties and structural characteristics.
Used in Research and Development:
1-(2-bromophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline is used as a research tool for studying the biological activities and potential applications of isoquinoline derivatives in various fields, including medicinal chemistry and pharmacology.

Upstream product

• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 96733-87-8 2-Bromo-N-(2-bromo-phenyl)-N-[2-(3-methoxy-phenyl)-ethyl]-benzamide 
• 96718-83-1 2-Bromo-N-[2-(3-methoxy-phenyl)-ethyl]-N-phenyl-benzamide 
• 96718-67-1 N-(2-Bromo-phenyl)-2-(3-methoxy-phenyl)-acetamide 
• 96718-72-8 (2-Bromo-phenyl)-[2-(3-methoxy-phenyl)-ethyl]-amine 
• 85274-96-0 2-(3-Methoxy-phenyl)-N-phenyl-acetamide 
• 1798-09-0 m-methoxyphenylacetic acid 
• 96719-14-1 1-(2-Bromo-phenyl)-6-methoxy-2-phenyl-3,4-dihydro-isoquinolinium; iodide 
• 51009-27-9 [2-(3-Methoxy-phenyl)-ethyl]-phenyl-amine 

Relevant academic research and scientific papers

Antiimplantation Agents: Part II - 1,2-Diaryl-1,2,3,4-tetrahydroisoquinolines

1,2-Diaryl-3,4-dihydroisoquinolinium derivatives (5) have been synthesised from N-aryl-N-aroyl-β-phenethylamines (4) and found to exhibit no antiimplantation activity in the rat whereas many of the corresponding tetrahydroisoquinolines (6) are active.Structure-activity relationships have also been studied. 1-(p-Fluorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline (6u) and its nor derivative (6v) are very potent, while the ortho (6g) and the meta (6n) fluoro analogues as well as the des-fluoro derivative (6d) are quite active.Extensive biological tests have been carried out on 6g.The enantiomers (+)-6p*HCl and (-)-6q*HCl of 6n have similar activity profiles as that of 6n showing no separation of antiimplantation and estrogenic properties.Diastereomeric 2-(2-methyl-2-phenethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinolines (13a and 13b) show similar properties, while the tetracyclic derivative 19 is inactive. 2-Phenoxyethyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (26) shows moderate activity, but 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline 29 is inactive.