96747-25-0

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 128120-97-8 phenylalanine phenacyl ester trifluoroacetate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 96746-63-3 N,N'-bis<(2S)-2-((2-oxo-2-phenyl)ethoxy)-2-oxo-1-benzyl>-3,5-bis(aminocarbonyl)pyridine 
• 96746-66-6 (4S,14S)-4,14-dibenzyl-6,9,12-trioxa-2,5,13,16-tetraoxo-3,15,19-triazabicyclo<15.3.1>heneicosa-1(21),17,19-triene 
• 96747-45-4 (4S,14S)-4,14-Dibenzyl-6,12-dioxa-3,15,19-triaza-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene-2,5,13,16-tetraone 
• 96747-48-7 (4S,14S)-4,14-Dibenzyl-9,9-dimethyl-6,12-dioxa-3,15,19-triaza-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene-2,5,13,16-tetraone 
• 763121-21-7 phenacyl N-(1-naphthylacetyl)phenylalaninate 
• 763121-20-6 phenacyl N-(phenylacetyl)phenylalaninate 
• 105990-13-4 t-Boc-Phe-D-Leu-OH 
• 99597-71-4 methyl-(N-Boc-L-phenylalanine)-D-leucinate 
• 33014-68-5 tert-butoxycarbonyl-L-phenylalanyl-L-leucine 
• 64152-76-7 methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate 
• 6479-55-6 L-phenylalanine phenacyl ester hydrobromide 
• 252315-91-6 (S)-tert-butyl (2-phenyl-1-(4-phenyl-1H-imidazol-2-yl)ethyl)carbamate 

Relevant academic research and scientific papers

Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity

Novel inhibitors of FXIa containing an (S)-2-phenyl-1-(4-phenyl-1H-imidazol-2-yl)ethanamine core have been optimized to provide compound 16b, a potent, reversible inhibitor of FXIa (Ki = 0.3 nM) having in vivo antithrombotic efficacy in the rabbit AV-shunt thrombosis model (ID50 = 0.6 mg/kg + 1 mg kg-1 h-1). Initial analog selection was informed by molecular modeling using compounds 11a and 11h overlaid onto the X-ray crystal structure of tetrahydroquinoline 3 complexed to FXIa. Further optimization was achieved by specific modifications derived from careful analysis of the X-ray crystal structure of the FXIa/11h complex. Compound 16b was well tolerated and enabled extensive pharmacologic evaluation of the FXIa mechanism up to the ID90 for thrombus inhibition.

A novel and efficient method for cleavage of phenacylesters by magnesium reduction with acetic acid

(Equation Presented) In the present study, we use magnesium turnings as a new deprotection reagent for the phenacyl group during orthogonal organic synthesis in the presence of other esters and sensitive protecting groups. By applying the new magnesium turnings/acetic acid deprotection method, phenacyl group can be more easily combined with other protecting groups that are not compatible with the zinc/acetic acid method.

Intramolecular triplet-triplet energy transfer in short flexible bichromophoric amino acids, dipeptides and carboxylic acid diester

Efficiencies of the intramolecular triplet-triplet energy transfer (ITET) in various bichromophoric amino acids (glycine, valine, phenylalanine, and sarcosine), dipeptides (glycylglycine, phenylalanylphenylalanine), and a simple diester, with the benzoyl