96750-66-2 Usage
Uses
Used in Neuroscience Research:
Chlorisondamine diiodide is used as a nicotinic receptor antagonist for testing its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis. It helps in understanding the role of nAChRs in inflammatory bowel diseases.
Used in Neuropharmacology:
Chlorisondamine diiodide is used as an irreversible nicotinic acetylcholine (nAChR) blocker to pre-treat brain samples, allowing researchers to test its effect on cytochrome P450 2B (CYP2B) induction. This helps in studying the regulation of drug-metabolizing enzymes in the brain.
Used in Stress and Neuroendocrine Research:
Chlorisondamine diiodide is used as a ganglionic blocker to test its effect on regulating corticosterone levels in rats with chronic stress. This aids in understanding the role of ganglionic transmission in stress response and neuroendocrine regulation.
Biochem/physiol Actions
Chlorisondamine diiodide mediates ganglionic and central blockade.
Check Digit Verification of cas no
The CAS Registry Mumber 96750-66-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,7,5 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 96750-66:
(7*9)+(6*6)+(5*7)+(4*5)+(3*0)+(2*6)+(1*6)=172
172 % 10 = 2
So 96750-66-2 is a valid CAS Registry Number.
96750-66-2Relevant academic research and scientific papers
Zezula, Josef,Wang, Hay-Yan J.,Woods, Amina S.,Wise, Roy A.,Jacobson, Arthur E.,Rice, Kenner C.
, p. 471 - 478 (2006)
Chlorisondamine is a bisquaternary ganglion-blocking nicotinic antagonist that accumulates in dopaminergic, serotonergic, and noradrenergic cell bodies; the mechanism of uptake and time-course of retrograde transport are not known. Chlorisondamine could possibly be taken into monoaminergic neurons when blocked nicotinic receptors on those cells are internalized. In order to more easily study the mechanism of the capture and recycling of chlorisondamine, a ligand is needed that has high specific activity. For that purpose, we now report the preparation of 3H-labeled chlorisondamine (4,5,6,7-tetrachloro-2- [3H]methyl-2-(2-trimethylammoniumethyl)-isoindolinium diiodide) of high specific activity (94 Ci/mmol). The compound was synthesized by quarternization of 4,5,6,7-tetrachloro-2-(2-trimethylammoniumethyl-isoindolinium iodide with pertritiated methyl iodide in dimethylformamide at high temperature in a sealed vessel. Copyright
