96772-50-8Relevant academic research and scientific papers
Amino Acids: Nontoxic and Cheap Alternatives for Amines for the Synthesis of Benzoxazoles through the Oxidative Functionalization of Catechols
Aberi, Mahdi,Aboonajmi, Jasem,Sharghi, Hashem,Shekouhy, Mohsen
, p. 1064 - 1083 (2020)
The nano magnetic Fe3O4 (NM?Fe3O4) was applied for the synthesis of benzoxazoles via a C(aryl)?OH functionalization of catechol derivatives and amines in ethanol at room temperature. In the next step, amino acids have been applied as nontoxic and cheap alternatives for amines. The obtained products were similar with the regular amines case. This is the first report about the application of amino acids as alternatives for primary amines in organic synthesis. Furthermore, the presented method was successfully applied toward the synthesis of desired products in large scales. (Figure presented.).
Consecutive Oxidation/Condensation/Cyclization/Aromatization Sequences Catalyzed by Nanostructured Iron(III)-Porphyrin Complex towards Benzoxazole Derivatives
Aberi, Mahdi,Aboonajmi, Jasem,Sharghi, Hashem,Shiri, Pezhman
, p. 5978 - 5984 (2020/10/02)
A facile, efficient, and eco-friendly strategy to access benzoxazole heterocyclic products has been accomplished through oxidation of catechols followed by condensation/cyclization/aromatization sequences. This process is catalyzed by nanostructured iron(III)-porphyrin complex to form desired benzoxazole derivatives at room temperature under air condition. The procedure is widely applicable to diverse amines, and can provide the heterocyclic products in a scalable fashion, as well. One of the most significant types of oxidizing agents in nature is the iron-porphyrin complexes (0.1 mol-%), existing in the structure of hemoglobin. They have benefits such as low toxicity and high oxidation potential for many substrates.
