96780-79-9Relevant academic research and scientific papers
Potential Diuretics: Part I - Synthesis of Some Substituted 2,4-Dihydro-1-oxo/thioxotriazolobenzoxazines, Novel Diuretic Agents
Shridhar, D. R.,Jogibhukta, M.,Krishnan, V. S. H.,Joshi, P. P.,Naidu, M. U. R.,et al.
, p. 1279 - 1283 (2007/10/02)
Several compounds (V) derived from 2,4-dihydro-1-oxobenzoxazine and some of their 1-thioxo analogues (VI) have been synthesized and evaluated for their diuretic activity in rats.Compound Vg is the most potent member of this series with 250percent urine output of the saline control at 1 mg/kg dose.The pattern of excretion of electrolytes is similar to that of the hydrochlorothiazide at the same dose.Furthermore, its diuretic activity is very much dose-dependent over a wide range of doses (1.0-32.0 mg/kg).
