96799-02-9

Basic information

• Product Name: 3-(2-FURYL)-1H-PYRAZOL-5-AMINE
• Synonyms: 3-(2-FURYL)-1H-PYRAZOL-5-AMINE;3-AMINO-5-(2-FURYL)PYRAZOLE;5-(2-FURYL)-1H-PYRAZOL-3-AMINE;5-(FURAN-2-YL)-1H-PYRAZOL-3-AMINE;5-AMINO-3-FUR-2-YLPYRAZOLE;5-AMINO-3-(2-FURYL)PYRAZOLE;BUTTPARK 33\04-37;TIMTEC-BB SBB005496
• CAS NO: 96799-02-9
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 149.15
• EINECS: -0
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 96799-02-9.mol

Chemical Properties

• Melting Point: 126-130 °C(lit.)
• Boiling Point: 429.9 °C at 760mmHg
• Flash Point: 213.8 °C
• Appearance: Brown crystalline powder
• Density: 1.339 g/cm³
• Vapor Pressure: 1.35E-07mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.80±0.10(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 4399373
• CAS DataBase Reference: 3-(2-FURYL)-1H-PYRAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-FURYL)-1H-PYRAZOL-5-AMINE(96799-02-9)
• EPA Substance Registry System: 3-(2-FURYL)-1H-PYRAZOL-5-AMINE(96799-02-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 96799-02-9(Hazardous Substances Data)

Usage

Uses

3-Amino-5-(2-furyl)-1H-pyrazole is used as a pharmaceutical intermediate.

InChI:InChI=1/C7H7N3O/c8-7-4-5(9-10-7)6-2-1-3-11-6/h1-4H,(H3,8,9,10)

Upstream product

• 31909-58-7 2-furoylacetonitrile 

Downstream Products

• 96799-16-5 7-Furan-2-yl-2-phenyl-4-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a][1,3,5]triazine 
• 96799-14-3 2-(4-Chloro-phenyl)-7-furan-2-yl-4-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a][1,3,5]triazine 
• 1245236-05-8 C₁₉H₁₅Cl₂N₃O₃ 
• 1258211-97-0 C₂₂H₂₄FN₉O 
• 1258212-00-8 C₂₂H₂₅N₉O 
• 1258212-02-0 C₂₂H₂₄N₈OS 
• 1258211-99-2 C₂₂H₂₃FN₈OS 
• 1258212-03-1 C₂₃H₂₆FN₉O 
• 1258212-07-5 C₂₃H₂₆FN₉O 
• 1258211-98-1 C₂₃H₂₆FN₉O 
• 1258212-06-4 C₂₃H₂₆FN₉O 
• 1258222-74-0 C₂₁H₂₂N₈OS 
• 1258222-98-8 C₂₃H₂₃N₉O 
• 1258222-71-7 C₂₅H₂₇N₉O₂S 

Relevant articles and documents

ANTAGONISTS OF THE ADENOSINE A2A RECEPTOR

The present invention relates to compounds of formula I shown below: wherein R0, R1, R2, R3 and A are each as defined in the application. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or conditions in which adenosine A2a receptor activity is implicated, such as, for example, cancer.

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.

Novel Compounds

There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.