96818-22-3

Upstream product

• 96818-20-1 Sodium; 4-(2,4-dimethoxy-phenyl)-butyrate 
• 51114-95-5 (E)-4-(3’,5’-dimethoxyphenyl)but-3-enoic acid 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 96818-18-7 4-(3,5-dimethoxyphenyl)butanoic acid 

Downstream Products

• 96818-24-5 methyl N-<4-(2,4-dimethoxyphenyl)butanoyl>anthranilate 
• 87893-97-8 3-amino-2-<3-(2,4-dimethoxyphenyl)propyl>quinazol-4(3H)-one 

Relevant academic research and scientific papers

Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.

Intramolecular Reactions of N-Nitrenes: Oxidation of 3-Amino-2-(2,4-dimethoxyphenylpropyl)quinazolin-4(3H)-one

Oxidation of the title compound (3) and its gem-dimethyl-substituted analogue (10) in methanol gave the tetracyclic products (5) and (7), respectively.A solution of compound (5) in methanol was converted on standing into the cyclopentane ring-containing compound (8) whose structure was confirmed by X-ray crystallography.