96818-57-4

Upstream product

• 2361-27-5 2-thienylhydrazide 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 
• 527-72-0 2-thiophenylcarboxylic acid 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 2810-04-0 Ethyl thiophene-2-carboxylate 

Downstream Products

• 97161-34-7 monochloro(N-(thiophene-2-carboxamido)salicylaldiminato)cobalt(II) 
• 925546-95-8 monochloro(N-(thiophene-2-carboxamido)salicylaldiminato)copper(II) 
• 97161-38-1 monochloro(N-(thiophene-2-carboxamido)salicylaldiminato)nickel(II) 

Relevant academic research and scientific papers

A simple turn-on ESIPT and PET-based fluorescent probe for detection of Al3+ in real-water sample

Aluminum is known as the most ubiquitous metal in earth's crust but its excessive exposure will cause damage to environment and health of the organism. Here, a turn-on Schiff base fluorescence probe STH based on excited state intramolecular proton transfe

BF3-Etherate-catalyzed tandem reaction of 2-formylarylketones with electron-rich arenes/heteroarenes: An assembly of isobenzofurans

An efficient and BF3·Et2O-catalyzed chemoselective synthesis of diversified 1,3-diarylisobenzofuran in a high yield has been described. The reaction proceeds through sequential hydroarylation-cyclization between 2-formylarylketones and electron-rich arenes/heteroarenes. Advantageous features of the developed methodology include operational simplicity, a broad substrate scope, and applicability towards gram scale synthesis. The utility of isobenzofuran derivatives as the diene was extended to the synthesis of [4+2] cyclo-adducts with DMAD and the synthesis of 1,2-dicarbonylarenes in good yields.

N-acylhydrazones containing thiophene nucleus: a new anticancer class

In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC50) ranged from 0.82 to 12.90 μM. The compound (E)-N′-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed good cytotoxic activity in all cell lines (IC50 = 0.82–5.36 μM) and yielded the best result in this series; therefore, it is an important lead compound in this new class.

Design, Synthesis, and in vitro Antimicrobial Activity of New Furan/Thiophene-1,3-Benzothiazin-4-one Hybrids

This study presents the design, synthesis, spectral analysis, and in vitro antimicrobial evaluation of a new series of furan/thiophene-1,3-benzothiazin-4-one hybrids (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32). New compounds were obtained by cyclization reaction of N-substituted furan/thiophene-2-carboxamide derivatives (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16) with thiosalicylic acid. All synthesized compounds were screened for their in vitro antimicrobial activities using the broth microdilution method. Nine of the synthesized compounds showed good activity against Gram-positive, Gram-negative bacteria, and yeasts belonging to Candida spp. (MIC = 7.81-500 μg/mL), especially against Staphylococcus spp. (MIC = 15.62-62.5 μg/ml), Bacillus spp. (MIC = 7.81-62.5 μg/mL), Bordetella bronchiseptica ATCC 4617 (MIC = 62.5-125 μg/mL), and fungistatic activity against Candida spp. (MIC = 62.5-125 μg/mL).

Acylhydrazide schiff bases: Synthesis and antiglycation activity

Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 μM), 27 (IC50 = 234.83 ± 10.28 μM), 2 (IC50 = 240.99 ± 4.2 μM), and 14 (IC50 = 276.2 ± 2.3 μM) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 ± 1.5 μM). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques.

Acylhydrazide Schiff bases: DPPH radical and superoxide anion scavengers

Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25-473.59 μM. Compounds 8, 2, and 10 have IC50 values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 μM, respectively. Standard npropylgallate showed an IC50 value 30.12 ± 0.27 μM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6-450.89 μM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 ± 1.6 μM).

SYNERGISTIC FUNGICIDAL AND ALGICIDAL COMPOSITIONS INCLUDING 2-HYDROXYPHENYLALDEHYDE AND 2-HYDROXYPHENYLKETONE HETEROCYCLOYLHYDRAZONES AND COPPER

The present invention relates to the use of mixtures containing 2-hydroxyphenylaldehyde and 2-hydroxyphenylketone heterocycloylhydrazone compounds and copper for controlling the growth of fungi and algae.

Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor

A systematically generated series of hydrazones were analyzed as potential inhibitors of anthrax lethal factor. The hydrazones were screened using one UV-based and two fluorescence-based in vitro assays. The study identified several inhibitors with IC50 values in the micromolar range, and importantly, significant differences in the types of inhibition were observed with the different assays.

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the

Synthesis of New Acylhydrazones as Iron-Chelating Compounds

Fourteen acylhydrazides have been condensed with three aromatic o-hydroxy aldehydes (pyridoxal, salicylaldehyde, and 2-hydroxy-1-naphthaldehyde) to give 42 acylhydrazones, of which 38 are new.These compounds complex iron and have shown varying abilities to promote the movement of iron across biological membranes.Their infrared and nuclear magnetic resonance spectra support the structures assigned to them.