96847-89-1

Upstream product

• 31953-80-7 N-tert-butyloxycarbonyl-(2S)-prolyl-glycine benzyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 64918-37-2 Boc-L-Val-Gly-OBzl 
• 13734-41-3 t-Boc-L-valine 
• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 74939-29-0 H-Val-Gly-OBzl*TFA 
• 63276-49-3 Boc-Val-Pro-Gly-OH 

Downstream Products

• 719264-54-7 VPGVG-OBzl 
• 76911-65-4 Boc-VPGVGVPGVG-OBzl 

Relevant academic research and scientific papers

Crystal Structures of Repeating Peptides of Elastin. 1. N-(tert-Butoxycarbonyl)-L-valyl-L-prolyglycyl-L-valylglycine

The crystal structure of the pentapeptide Boc-Val1-Pro2-Gly3-Val4-Gly5-OH, one of the repeating sequences of tropoelastin, has been determined by the X-ray diffraction method.It crystallizes as a mono

Synthesis of temperature-dependent elastin-like peptide-modified dendrimer for drug delivery

Dendrimers are synthetic macromolecules with a unique structure that are potential unimolecular drug carriers and potential scaffolds for peptides. Elastin is one of the main components of the extracellular matrix, as well as a temperature-sensitive biomacromolecule. Val-Pro-Gly-Val-Gly repeats, an elastin-like peptide, have been used for designing artificial elastin molecules. In this study, we have synthesized a novel type of temperature-dependent drug carrier by conjugating Ac-Val-Pro-Gly-Val-Gly to a dendrimer, named elastin-mimetic dendrimer. The elastin-mimetic dendrimer formed β-turn structure by heating. The elastin-mimetic dendrimer exhibited the inverse phase transition, depending on pH and NaCl concentration in addition to temperature. The elastin-mimetic dendrimer could encapsulate a model drug, rose bengal, even though the complex stability was similar to the dendrimer without elastin-like peptide. Therefore, the elastin-mimetic dendrimer is a potential drug carrier with temperature- and pH-dependent properties. (134 words)