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5-(N-Methyl-N-isobutyl)amiloride is a chemical compound that functions as an NHE (sodium-hydrogen exchanger) inhibitor. It is characterized by its ability to inhibit bacterial and mitochondrial NADH-quinone oxidoreductase, also known as complex I, which plays a crucial role in cellular respiration and energy production.

96861-65-3

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96861-65-3 Usage

Uses

Used in Pharmaceutical Industry:
5-(N-Methyl-N-isobutyl)amiloride is used as a research chemical for studying the role of NHE inhibitors in various biological processes and diseases. Its ability to inhibit complex I in both bacterial and mitochondrial systems makes it a valuable tool for investigating the mechanisms of energy production and their implications in health and disease.
Used in Scientific Research:
5-(N-Methyl-N-isobutyl)amiloride is used as an experimental compound in scientific research to explore the effects of NHE inhibition on cellular functions, particularly in the context of complex I activity. This can provide insights into the development of potential therapeutic agents targeting these pathways for the treatment of various disorders.
Used in Drug Development:
5-(N-Methyl-N-isobutyl)amiloride serves as a lead compound in drug development efforts aimed at discovering new treatments for conditions related to NHE activity and mitochondrial function. Its inhibitory properties can be leveraged to develop novel therapeutic agents that modulate cellular respiration and energy metabolism.
Used in Toxicology Studies:
5-(N-Methyl-N-isobutyl)amiloride is used in toxicology studies to evaluate the potential harmful effects of NHE inhibition on cellular processes. Understanding the consequences of inhibiting complex I can help in assessing the safety and efficacy of compounds targeting these pathways for therapeutic use.

Check Digit Verification of cas no

The CAS Registry Mumber 96861-65-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,8,6 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 96861-65:
(7*9)+(6*6)+(5*8)+(4*6)+(3*1)+(2*6)+(1*5)=183
183 % 10 = 3
So 96861-65-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

96861-65-3 Well-known Company Product Price

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  • Sigma

  • (A5585)  5-(N-Methyl-N-isobutyl)-amiloride  ≥98% (TLC), powder

  • 96861-65-3

  • A5585-25MG

  • 2,035.80CNY

  • Detail

96861-65-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-amino-6-chloro-N-(diaminomethylidene)-5-[methyl(2-methylpropyl)amino]pyrazine-2-carboxamide

1.2 Other means of identification

Product number -
Other names 5-Nmnia

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:96861-65-3 SDS

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