96866-10-3

Upstream product

• 73136-26-2 (R)-2-bromo-3-phenylpropionic acid methyl ester 
• 673-06-3 D-(R)-phenylalanine 
• 42990-55-6 (S)-(alpha)-bromobenzenepropanoic acid 
• 215512-44-0 (S)-2-Benzyloxyamino-3-phenyl-propionic acid methyl ester 

Downstream Products

• 96866-11-4 N-(benzyloxy)-N-formyl-L-phenylalanine 
• 215512-46-2 (S)-2-((2S,3S)-2-{(S)-2-[Benzyloxy-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-amino]-3-phenyl-propionylamino}-3-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester 
• 87429-09-2 N-benzyloxy 2-formamido 3-phenyl propanoic acid 
• 96866-12-5 N-(benzyloxy)-N-formyl-L-phenylalanylglycine benzyl ester 
• 96866-13-6 N-(benzyloxy)-N-formyl-L-phenylalanylglycine isopentylamide 
• 87438-04-8 N-formyl-N-hydroxy-L-phenylalanylglycine isopentyl amide 
• 87438-06-0 N-formyl-N-hydroxy-L-phenylalanylglycine 

Relevant academic research and scientific papers

Synthesis and activity of HIV protease inhibitors

We report here the synthesis and activity of HIV protease inhibitors. In the first stage hydrophobic compounds incorporating a 'carba' bond surrogate or a beta-homologated residue were synthesized. Secondly, we synthesized cyclic compounds in which we incorporated 2-quinoline carboxylic acid in the P3 position and the amino-hydroxyindane moiety in the P'3. The last part of this work was dedicated to a structure/activity study of a peptide substrate. These modifications allowed us to work up the synthesis of new pseudopeptide bonds: amino-amide and hydroxy-amide. Compounds with activity in the micromolar range were actually a starting point for the synthesis of new protease inhibitors.