96866-37-4Relevant academic research and scientific papers
Aza-Rubottom Oxidation: Synthetic Access to Primary α-Aminoketones
Zhou, Zhe,Cheng, Qing-Qing,Kürti, László
supporting information, (2019/02/14)
An aza analogue of the Rubottom oxidation is reported. This facile transformation takes place at ambient temperature and directly converts silyl enol ethers to the corresponding primary α-aminoketones. The use of hexafluoroisopropanol (HFIP) as the solven
Aminotetralone Analogues of Ketamine: Synthesis and Evaluation of Hypnotic and Locomotor Properties in Mice
Yang, David J.,Davisson, John N.
, p. 1361 - 1365 (2007/10/02)
Ketamine and phencyclidine are structurally similar compounds that share many pharmacological actions, some of which are similar to the phenethylamines amphetamine and cathione.In order to integrate structural features of ketamine and cathinone, two groups of analogues, which are more conformationally restricted compared to the parent compounds, were synthesized for biological evaluation.These included 1-amino-1-methyl-2-tetralone and 2-amino-2-methyl-1-tetralone was well as several N-substituted derivatives of these molecules.Locomotor activity testing in mice revealed that 2-amino-2-methyl-1-tetralone caused an increase in locomotor activity while 1-amino-1-methyl-2-tetralone depressed soontaneous locomotor activity.None of the compounds produced hypnosis or profound ataxia.
