96876-91-4

Upstream product

• 95-51-2 o-chloroaniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Downstream Products

• 1421606-52-1 ethyl 8-chloro-4-ethoxyquinoline-2-carboxylate 
• 1421606-69-0 (E)-8-chloro-4-methoxy-N-(4-methoxystyryl)quinoline-2-carboxamide 
• 1421606-70-3 (E)-8-chloro-N-(2,5-dimethoxystyryl)-4-methoxyquinoline-2-carboxamide 
• 1421606-71-4 (E)-8-chloro-4-methoxy-N-(3,4,5-trimethoxystyryl)quinoline-2-carboxamide 
• 1421606-72-5 (E)-8-chloro-4-ethoxy-N-(4-(methylthio)styryl)quinoline-2-carboxamide 
• 1421606-80-5 (E)-8-chloro-N-(4-isopropylstyryl)-4-methoxyquinoline-2-carboxamide 
• 1421606-81-6 (E)-N-(4-tert-butylstyryl)-8-chloro-4-ethoxyquinoline-2-carboxamide 
• 1421606-82-7 (E)-8-chloro-4-ethoxy-N-styrylquinoline-2-carboxamide 

Relevant academic research and scientific papers

Gold catalyzed synthesis of tetrahydropyrimidines and octahydroquinazolines under ball milling conditions and evaluation of anticonvulsant potency

A fast, mechanochemical and solvent-free synthesis of substituted tetrahydropyrimidines and octahydroquinazolines under Au(III)-catalysis has been developed. The practical feasibility, eco-friendliness and operational simplicity of this chemistry is exemplified by ball milling three components such as formaldehyde, amines and 2-butynedioates/dimedone in a shaker mill for as little as five minutes, thus avoiding the requirement of undesirable solvents and long reaction times. Moreover, this protocol furnishes the target compounds in high yields without any side products and in some cases offers products with excellent regioselectivity. Out of the 26 compounds screened for anticonvulsant potency, 11 compounds exhibited comparable activity against a standard drug.

Hydroamination reactions of alkynes with ortho-substituted anilines in ball mills: Synthesis of benzannulated N-heterocycles by a cascade reaction

It was demonstrated that ortho-substituted anilines are prone to undergo hydroamination reactions with diethyl acetylenedicarboxylate in a planetary ball mill. A sequential coupling of the intermolecular hydroamination reaction with intramolecular ring cl

Synthesis of perspicamide A and related diverse analogues: Their bioevaluation as potent antileishmanial agents

The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues, 24a, 24b, 24c, 24d, and 24l, exhibited potent activ