96895-52-2

Upstream product

• 86534-78-3 (2R,3S,3aR,5R,6S)-3a-Allyl-5-methoxy-3-methyl-2-(3,4,5-trimethoxy-phenyl)-hexahydro-benzofuran-6,7a-diol 
• 86534-77-2 (2R,3S,3aR,5R,6S)-3a-Allyl-5,6-dimethoxy-3-methyl-2-(3,4,5-trimethoxy-phenyl)-hexahydro-benzofuran-7a-ol 
• 86534-76-1 (2R,3S,3aR,5R,6S)-3a-Allyl-5,6,7a-trimethoxy-3-methyl-2-(3,4,5-trimethoxy-phenyl)-octahydro-benzofuran 
• 96851-93-3 (S)-2-((1R,5R)-1-Allyl-5-methoxy-2-oxo-cyclohex-3-enyl)-propionaldehyde 
• 81952-68-3 1-lithio-3,4,5-trimethoxybenzene 
• 96851-92-2 (4R,6R)-6-Allyl-4-methoxy-6-((S)-1-methyl-2,2-bis-methylsulfanyl-ethyl)-cyclohex-2-enone 
• 96851-83-1 (S)-3-Eth-(Z)-ylidene-5-trityloxymethyl-dihydro-furan-2-one 
• 96851-84-2 (S)-3-Eth-(E)-ylidene-5-trityloxymethyl-dihydro-furan-2-one 
• 96851-82-0 Lithium; (S)-5-trityloxymethyl-4,5-dihydro-furan-2-olate 
• 96851-88-6 (R)-2-((S)-2-Methoxy-3-trityloxy-propyl)-2-((S)-1-methyl-2,2-bis-methylsulfanyl-ethyl)-pent-4-enoic acid methyl ester 
• 96851-89-7 (R)-3-((S)-2-Methoxy-3-trityloxy-propyl)-3-((S)-1-methyl-2,2-bis-methylsulfanyl-ethyl)-hex-5-en-2-one 
• 96851-91-1 (2S,4R)-4-Acetyl-2-methoxy-4-((S)-1-methyl-2,2-bis-methylsulfanyl-ethyl)-hept-6-enal 
• 96851-90-0 (R)-3-((S)-3-Hydroxy-2-methoxy-propyl)-3-((S)-1-methyl-2,2-bis-methylsulfanyl-ethyl)-hex-5-en-2-one 
• 78108-40-4 (2β,3β,3aα,5β)-3,3a,4,5-tetrahydro-5-methoxy-3-methyl-3a-<3-<(methylsulfonyl)oxy>propyl>-2-(3,4,5-trimethoxyphenyl)-6(2H)-benzofuranone 

Relevant academic research and scientific papers

ENANTIOSPECIFIC TOTAL SYNTHESIS OF (-)-MEGAPHONE BY A HIGHLY CONTROLLED CONSECUTIVE 1,4- AND 1,3-ASYMMETRIC INDUCTION.

Enantiospecific total synthesis of (-)-megaphone (1) is reported.The key synthetic tactic is the use of (4S)-2Z-ethylidene-4-trityloxymethyl-butan-4-olide (6) to both establish the relative and absolute stereochemistry of the contiguous tertiary and quate

TOTAL SYNTHESIS OF d,l-MEGAPHONE

The synthesis of racemic megaphone 1, a cytotoxic neolignan, is described

The Synthesis of Megaphone

Condensation of 4,4,5-trimethoxy-2-propyl>-2,5-cyclohexadien-1-one (7) with 1,2,3-trimethoxy-5-(1-(Z)-propenyl)benzene in dichloromethane, in the presence of 1 equiv. of stannic chloride, gave (2β,3β,3aα)-3,3a-dihydro-5-methoxy-3-m