96914-39-5 Usage
Originator
Dizactamide ,ZYF Pharm Chemical
Manufacturing Process
Hydrogenation of 4-diisopropylamino-2-phenyl-2-pyridin-2-yl-butyramide over
platinum oxide catalyst reduced the pyridine ring to a piperidine to give 4-
diisopropylamino-2-phenyl-2-piperidin-2-yl-butyramide as a white solid, MP:
107°-108°C. Structure was confirmed by proton, carbon-13-NMR spectra and
by elemental analysis.
2-(1-Acetylpiperidin-2-yl)-4-diisopropylamino-2-phenylbutyramide was
prepared by acetylation of above product with N,N-dimethylacetamide
dimethylacetal by heating at 80°C for about 14 hours. The acetamide melted
at 191°-192°C. The treatment of that intermediate with lithium aluminum
hydride led the newly introduced acetyl group to condense with the adjacent
amide nitrogen. There was thus obtained 4-(2-diisopropylaminoethyl)-1-
methyl-4-phenyl-4,4a,5,6,7,8-hexahydropyrido[1,2-c]pyrimidin-3-one, the
new anti-arrhythmic agent actisomide, MP: 70°-75°C. Its structure was
confirmed by proton NMR and infrared spectra and by elemental analysis.
Brand name
Cardiac
depressant (anti-arrhythmic).
Therapeutic Function
Cardiac depressant
Check Digit Verification of cas no
The CAS Registry Mumber 96914-39-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,9,1 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 96914-39:
(7*9)+(6*6)+(5*9)+(4*1)+(3*4)+(2*3)+(1*9)=175
175 % 10 = 5
So 96914-39-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H35N3O/c1-17(2)25(18(3)4)16-14-23(20-11-7-6-8-12-20)21-13-9-10-15-26(21)19(5)24-22(23)27/h6-8,11-12,17-18,21H,9-10,13-16H2,1-5H3/t21-,23-/m1/s1
96914-39-5Relevant academic research and scientific papers
Synthesis and Structure-Activity Relationships of a New Series of Antiarrhytmic Agents: 4,4-Disubstituted Hexahydro-3H-pyridopyrimidin-3-ones and Related Compounds
Chorvat, Robert J.,Prodan, Kathleen A.,Adelstein, Gilbert W.,Rydzewski, Robert M.,McLauglin, Kathleen T.,et al.
, p. 1285 - 1291 (2007/10/02)
A series of 4,4-disubstituted tetrahydro- and 4,4-disubstituted hexahydro-3H-pyridopyrimidin-3-ones (4 and 5, respectively) were prepared from 2-aryl-2-(2-piperidinyl)-4-butanamides (2).Individual racemates of the piper
