96920-90-0Relevant academic research and scientific papers
Method for synthesizing alpha-fluorinated ketone through hydrazone aliphatic chain monoketone
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Paragraph 0077-0079, (2021/02/06)
The invention belongs to the technical field of organic synthesis, and provides a method for synthesizing alpha-ketone fluoride through hydrazone aliphatic chain monoketone, which comprises the following steps of: reacting aliphatic chain monoketone with hydrazine hydrate to obtain hydrazone, and reacting hydrazone with a compound represented by formula 2 under a heating condition to complete hydrazone defluorination. The fluorinated product is widely applied to medicines, the reaction conditions are mild, and the process is simple.
MONO ET DIFLUORATION ELECTROCHIMIQUES DE GROUPES BENZYLIQUES
Laurent, Eliane,Marquet, Bernard,Tardivel, Robert
, p. 4431 - 4444 (2007/10/02)
Anodic oxidation of benzylic compounds 1 using CH3CN as a solvent and Et3N,3HF as a fluorinating reagent allowed to introduce a fluorine atom in α position of electron withdrawing group via carbocation 1+ (ECBECN mechanism).Whatever the E group, monofluorides 2 are obtained in good yields from paramethoxy derivatives 1 (R=p-OCH3).In this case, by raising the potential of working electrode after the monofluorination step, gem difluorides 3 can be directly prepared from 1.When the substituent of the phenyl ring is different of a methoxy group, a mixture of fluoride 2 and acetamide 4 is generally obtained and the ratio of these two compounds is related to cation stability.
NOUVELLE METHODE DE PREPARATION DE CETONES, ESTER ET NITRILE BENZYLIQUES α-FLUORES OU α,α-DIFLUORES
Laurent, E.,Marquet, B.,Tardivel, R.,Thiebault, H.
, p. 2359 - 2362 (2007/10/02)
By anodic oxidation in CH3CN/Et3N, 3HF benzylic ketones, ester and nitrile yield specifically corresponding monofluoro or difluoro compounds.The reaction proceeds through an α-carbonyl or an α-cyano carbocation.
