96935-61-4Relevant academic research and scientific papers
An improved route for the synthesis of Rolloamide B
Elagawany, Mohamed,Ibrahim, Mohamed A.
, p. 3837 - 3840 (2016/08/02)
A high yielding method for the synthesis of the cyclic heptapeptide Rolloamide B has been described. An effective isobutyl chloroformate (IBCF) mediated direct coupling reaction was introduced to improve the synthetic route towards Rolloamide B. Furthermo
Structure-Based Rationale Design and Synthesis of Aurantiamide Acetate Analogues - Towards a New Class of Potent Analgesic and Anti-inflammatory Agents
Suhas, Ramesh,Channe Gowda, Dase
, p. 850 - 862 (2012/06/04)
A series of new aurantiamide acetate analogues were synthesized by modifying its N-terminal substitution and the amino acid residue. The structure of all these compounds was established on the basis of analytical and spectral studies. All the new derivatives were evaluated in vivo for their analgesic activity by tail flick method in mice and anti-inflammatory activity against carrageenan-induced oedema in albino rats at different doses (25, 50 and 100mg/kg body weight). All the compounds exhibited significant pharmacological activity with no ulcerogenic liability. In particular, pentapeptides and tricosamers (30 amino acids) containing analogues have demonstrated high potency than the reference standards. These compounds hold promise for further development.
Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials - A novel approach to enhance biocompatibility
Suhas,Chandrashekar,Gowda, D. Channe
experimental part, p. 704 - 711 (2011/03/22)
The peptides of elastin sequences chosen for the present study included tetrapeptides, pentapeptides and tricosapeptides (30 amino acids), synthesized by classical solution phase method and conjugated to [3-(4-piperidyl)-6-fluoro- 1,2-benzisoxazole]. The
Hydrophobicity Dependence of Oxidation of Tetrapeptides of Elastin Sequences with Mn(III): Synthesis, Characterization, Kinetics, and Mechanistic Study
Kempe Gowda, B. K.,Prasad, H. S.,Rangappa, K. S.,Channe Gowda, D.
, p. 39 - 48 (2007/10/03)
The analogues of elastin sequences, glycyl-glycyl-alanyl-proline (GGAP), glycyl-glycyl-phenylalanyl-proline (GGFP), and glycyl-glycyl-isoleucyl-proline (GGIP) were synthesized by classical solution phase method and characterized. The kinetics of oxidation of these tetrapeptides (TETP) by Mn(III) has been studied in the presence of sulphate ions in acidic solution at 25 deg C. The reaction was followed spectrophotometrically at λmax = 500 nm. A first-order dependence of rate on both [Mn(III)] and [TETP] was observed. The rate is independent of the concentration of the reduction product, Mn(II), and hydrogen ions. The effects of varying the dielectric constant of the medium and addition of anions such as sulphate, chloride, or perchlorate were studied. Activation parameters have been evaluated using Arrhenius and Eyring plots. The oxidation products were isolated and characterized. A mechanism involving the reaction of TETP with Mn(III) in the rate-limiting step is suggested. An apparent correlation was noted between the rate of oxidation and the hydrophobicity of these sequences, where increased hydrophobicity results in increased rate of oxidation.
Non-linear hydrophobic-induced pKa shifts: Implications for efficiency of conversion to chemical energy
Urry, Dan W.,Gowda, D. Channe,Peng, Shao Qing,Parker, Timothy M.
, p. 67 - 74 (2007/10/02)
By using one Asp or one Glu per thirty residues in a polytricosapeptide capable of exhibiting a hydrophobic folding and assembly transition and stepwise converting a set of the five Val residues( most proximal to the Asp or Glu residue) to more-hydrophobi
CONFIGURATIONAL REQUIREMENTS OF AROMATIC AMINO ACID RESIDUES FOR THE ACTIVITY OF PRP-HEXAPEPTIDE
Kubik, Aleksandra,Szewczuk, Zbigniew,Siemion, Ignacy,Wieczorek, Zbigniew,Spiegel, Krystyna,et al.
, p. 2583 - 2590 (2007/10/02)
The three analogues with D-amino acid substituents at position 1 and 5 of PRP-hexapeptide were synthesized and tested for its biological activity to check the influence of the spatial orientation of aromatic rings on the immune response.One of the analogs
SYNTHESIS AND IMMUNOREGULATORY PROPERTIES OF FRAGMENTS OF A PROLINE-RICH POLYPEPTIDE FROM OVINE COLOSTRUM
Kubik, Aleksandra,Szewczuk, Zbigniew,Siemion, Ignacy Z.,Janusz, Maria,Wieczorek, Zbigniew,et al.
, p. 457 - 464 (2007/10/02)
Proline-rich-polypeptide (PRP) isolated from ovine colostrum produces a regulatory effect on the immune response.A nonapeptide fragment of PRP obtained by chymotryptic digestion (Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro) shows biological activity similar to PR
SYNTHESIS OF A HEPTAPEPTIDE WITH SEQUENCE 17 - 23 OF HUMAN CALCITONIN
Zel'tser, I. E.,Reshetnikova, I.Yu.,Borovkova, S. Yu.,Krysin, E. P.,Lavut, E. E.
, p. 449 - 456 (2007/10/02)
Two schemes for the synthesis of a peptide with sequence 17 - 23 of human calcitonin with the minimum protection of the lateral functions of the amino acids are proposed.
N-Carboxyalkylproline-containing tripeptides
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, (2008/06/13)
Certain N-carboxyalkyl prolyl-containing tripeptides have been prepared and found to improve kidney function. A species of the group of new compounds is N-(2-carboxyethyl)-L-prolyl-L-alanyl-L-proline which has diuretic activity and increases renal blood f
