96935-61-4

Upstream product

• 70462-58-7 benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate 
• 41324-66-7 H-Pro-OBzl 
• 124980-30-9 N-carbobenzoxy-L-proline phenylmethyl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 18942-49-9 Boc-D-Phe-OH 
• 64471-88-1 (S)-benzyl 1-((R)-2-(tert-butoxycarbonylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxylate 

Downstream Products

• 97423-72-8 Boc-Leu-D-Phe-Pro-OBzl 
• 137372-39-5 Boc-Gly-Phe-Pro-OBzl 
• 109539-09-5 HThrPheProOBzl 
• 1270202-61-3 Boc-GE(OcHx)GFP-OH 
• 1270202-28-2 Boc-GFGFP-OH 
• 1270202-38-4 C₄₄H₅₂FN₇O₈ 
• 1270202-56-6 C₂HF₃O₂*C₃₉H₄₄FN₇O₆ 
• 1374975-58-2 C₄₃H₅₄N₆O₉ 
• 1173882-19-3 (6S,9S,12S,14aS,20S,23S,25aS)-20-benzyl-6,12-di((S)-sec-butyl)-9-(hydroxymethyl)-23-isobutylhexadecahydro-1H-dipyrrolo[1,2-a:1',2'-j][1,4,7,10,13,16,19]heptaazacyclohenicosine-5,8,11,14,19,22,25(25aH)heptaone 
• 96625-35-3 ((2R,5S,10aS,10bS)-5-Benzyl-10b-hydroxy-3,6-dioxo-octahydro-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-carbamic acid tert-butyl ester 
• 96648-50-9 ((2S,5S,10aS,10bS)-5-Benzyl-10b-hydroxy-3,6-dioxo-octahydro-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-carbamic acid tert-butyl ester 
• 96625-30-8 Boc-Gly(OH)-Phe-Pro-ONp 
• 96625-29-5 Boc-Gly(OH)-Phe-Pro-OH 
• 98908-44-2 N-benzyloxycarbonyl-L-tyrosyl-L-valyl-L-prolyl-L-leucyl-L-phenylalanyl-L-proline benzyl ester 

Relevant academic research and scientific papers

An improved route for the synthesis of Rolloamide B

A high yielding method for the synthesis of the cyclic heptapeptide Rolloamide B has been described. An effective isobutyl chloroformate (IBCF) mediated direct coupling reaction was introduced to improve the synthetic route towards Rolloamide B. Furthermo

Structure-Based Rationale Design and Synthesis of Aurantiamide Acetate Analogues - Towards a New Class of Potent Analgesic and Anti-inflammatory Agents

A series of new aurantiamide acetate analogues were synthesized by modifying its N-terminal substitution and the amino acid residue. The structure of all these compounds was established on the basis of analytical and spectral studies. All the new derivatives were evaluated in vivo for their analgesic activity by tail flick method in mice and anti-inflammatory activity against carrageenan-induced oedema in albino rats at different doses (25, 50 and 100mg/kg body weight). All the compounds exhibited significant pharmacological activity with no ulcerogenic liability. In particular, pentapeptides and tricosamers (30 amino acids) containing analogues have demonstrated high potency than the reference standards. These compounds hold promise for further development.

Synthesis of elastin based peptides conjugated to benzisoxazole as a new class of potent antimicrobials - A novel approach to enhance biocompatibility

The peptides of elastin sequences chosen for the present study included tetrapeptides, pentapeptides and tricosapeptides (30 amino acids), synthesized by classical solution phase method and conjugated to [3-(4-piperidyl)-6-fluoro- 1,2-benzisoxazole]. The

Hydrophobicity Dependence of Oxidation of Tetrapeptides of Elastin Sequences with Mn(III): Synthesis, Characterization, Kinetics, and Mechanistic Study

The analogues of elastin sequences, glycyl-glycyl-alanyl-proline (GGAP), glycyl-glycyl-phenylalanyl-proline (GGFP), and glycyl-glycyl-isoleucyl-proline (GGIP) were synthesized by classical solution phase method and characterized. The kinetics of oxidation of these tetrapeptides (TETP) by Mn(III) has been studied in the presence of sulphate ions in acidic solution at 25 deg C. The reaction was followed spectrophotometrically at λmax = 500 nm. A first-order dependence of rate on both [Mn(III)] and [TETP] was observed. The rate is independent of the concentration of the reduction product, Mn(II), and hydrogen ions. The effects of varying the dielectric constant of the medium and addition of anions such as sulphate, chloride, or perchlorate were studied. Activation parameters have been evaluated using Arrhenius and Eyring plots. The oxidation products were isolated and characterized. A mechanism involving the reaction of TETP with Mn(III) in the rate-limiting step is suggested. An apparent correlation was noted between the rate of oxidation and the hydrophobicity of these sequences, where increased hydrophobicity results in increased rate of oxidation.

Non-linear hydrophobic-induced pKa shifts: Implications for efficiency of conversion to chemical energy

By using one Asp or one Glu per thirty residues in a polytricosapeptide capable of exhibiting a hydrophobic folding and assembly transition and stepwise converting a set of the five Val residues( most proximal to the Asp or Glu residue) to more-hydrophobi

SYNTHESIS AND IMMUNOREGULATORY PROPERTIES OF FRAGMENTS OF A PROLINE-RICH POLYPEPTIDE FROM OVINE COLOSTRUM

Proline-rich-polypeptide (PRP) isolated from ovine colostrum produces a regulatory effect on the immune response.A nonapeptide fragment of PRP obtained by chymotryptic digestion (Val-Glu-Ser-Tyr-Val-Pro-Leu-Phe-Pro) shows biological activity similar to PR

CONFIGURATIONAL REQUIREMENTS OF AROMATIC AMINO ACID RESIDUES FOR THE ACTIVITY OF PRP-HEXAPEPTIDE

The three analogues with D-amino acid substituents at position 1 and 5 of PRP-hexapeptide were synthesized and tested for its biological activity to check the influence of the spatial orientation of aromatic rings on the immune response.One of the analogs

SYNTHESIS OF A HEPTAPEPTIDE WITH SEQUENCE 17 - 23 OF HUMAN CALCITONIN

Two schemes for the synthesis of a peptide with sequence 17 - 23 of human calcitonin with the minimum protection of the lateral functions of the amino acids are proposed.

N-Carboxyalkylproline-containing tripeptides

Certain N-carboxyalkyl prolyl-containing tripeptides have been prepared and found to improve kidney function. A species of the group of new compounds is N-(2-carboxyethyl)-L-prolyl-L-alanyl-L-proline which has diuretic activity and increases renal blood f