96943-03-2Relevant academic research and scientific papers
Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors
Wang, Gang,Wang, Yutao,Wang, Lei,Han, Leiqiang,Hou, Xuben,Fu, Huansheng,Fang, Hao
, p. 7359 - 7365 (2015)
Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-
Selective Solid Phase Synthesis of Ureas and Hydantoins from Common Phenyl Carbamate Intermediates
Xiao, Xiao-Yi,Ngu, Khehyong,Chao, Corinne,Patel, Dinesh V.
, p. 6968 - 6973 (1997)
An efficient method for selective, solid phase synthesis of unsymmetrical ureas and hydantoins from a common phenyl carbamate dipeptide intermediate is decribed. Reaction of phenyl carbamate 6 with primary or secondary amines (R3R4NH) in THF results in selective formation of ureas 8, whereas its treatment with a tertiary amine base (iPr2NEt or DBU) in DMF affords clean conversion to hydantoins 10.
Design criteria for minimalist mimics of protein-protein interface segments
Taechalertpaisarn, Jaru,Lyu, Rui-Liang,Arancillo, Maritess,Lin, Chen-Ming,Jiang, Zhengyang,Perez, Lisa M.,Ioerger, Thomas R.,Burgess, Kevin
supporting information, p. 908 - 915 (2019/01/30)
Small molecules that can interrupt or inhibit protein-protein interactions (PPIs) are valuable as probes in chemical biology and medicinal chemistry, but they are also notoriously difficult to develop. Design of non-peptidic small molecules that mimic ami
LATENT INHIBITORS. PART 4. IRREVERSIBLE INHIBITION OF DIHYDRO-OROTATE DEHYDROGENASE BY HYDANTOINS DERIVED FROM AMINO ACIDS
Buntain, Ian G.,Suckling, Colin J.,Wood, Hamish C. S.
, p. 3175 - 3182 (2007/10/02)
Hydantoins and ureas derived from α-amino acids are shown to interact with dihydro-orotate dehydrogenase from Clostridium (Zymobacterium) oroticum, chiefly as weak competitive inhibitors but that the hydantoin derived from phenylalanine, 5-benzyl-3-(1-car
