96964-53-3

Basic information

• Product Name: 2-Naphthalenecarboxylic acid, 2-ethyl-1,2,3,4-tetrahydro-3-oxo-4-(phenylsulfonyl)-, methyl ester
• CAS NO: 96964-53-3
• Molecular Formula: C20H20O5S
• Molecular Weight: 372.442
• Mol File: 96964-53-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Naphthalenecarboxylic acid, 2-ethyl-1,2,3,4-tetrahydro-3-oxo-4-(phenylsulfonyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenecarboxylic acid, 2-ethyl-1,2,3,4-tetrahydro-3-oxo-4-(phenylsulfonyl)-, methyl ester(96964-53-3)
• EPA Substance Registry System: 2-Naphthalenecarboxylic acid, 2-ethyl-1,2,3,4-tetrahydro-3-oxo-4-(phenylsulfonyl)-, methyl ester(96964-53-3)

Safety Data

• Hazardous Substances Data: 96964-53-3(Hazardous Substances Data)

Upstream product

• 88116-02-3 1-bromomethyl-2-[(phenylsulfonyl)methyl]benzene 
• 26717-67-9 dimethyl ethylmalonate 

Downstream Products

• 96964-65-7 4-Benzenesulfonyl-2-ethyl-4-methyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester 
• 88116-08-9 1-(phenylsulfonyl)-2-oxo-3-ethyl-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Annulation Reactions Leading to Naphtalene Derivatives. New Syntheses of Natural 1,2- and 1,4-Naphthoquinones

1-(Phenylsulfonyl)-2-oxo-3-(methoxycarbonyl)-1,2,3,4-tetrahydronaphthalene derivatives with various C-3 substituents were effectively prepared by a one-step cyclization involving 1--2-(bromomethyl)benzene derivatives and monosubstituted malonic esters.A high yield one-step decarboxylation-desulfonylation of the above products by lithium iodide led to C-3-substituted 2-naphthalenols 7a-g whereas prior C-1 alkylation of the cyclization products provided 1,3-dialkylated 2-naphthalenols 6s,b.Oxidations of compounds 7 to o-naphthoquinones 8a-f further oxidations of the above products to substituted 2-hydroxy-1,4-naphthoquinones provided a new pathway to naturally occuring naphthoquinones like phthiocol (9), droserone methyl ether (10), and lapachol (15).