96969-83-4 Usage
Uses
Used in Pharmaceutical Industry:
1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone is used as an inhibitor of SIRT2 for its potential therapeutic applications. SIRT2 is a NAD+-dependent protein deacetylase that plays a crucial role in various cellular processes, including cell cycle regulation, DNA repair, and metabolism. Inhibition of SIRT2 has been shown to induce granulocytic differentiation in acute promyelocytic leukemia cell lines, such as NB4, making it a promising target for cancer therapy.
Used in Chemical Research:
1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone can be used as a research tool in chemical and biological studies. Its unique structure and properties allow scientists to investigate its interactions with various biomolecules and cellular targets. This can lead to a better understanding of its mechanism of action and potential applications in drug discovery and development.
Used in Dye Industry:
Due to its anthraquinone core and functional groups, 1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone may have potential applications as a dye in various industries, such as textiles, plastics, and printing inks. Its color properties and stability can be explored for use in different applications, providing a wide range of color options and improved performance compared to existing dyes.
in vitro
in a previou study, the molecular modeling and virtual screening were utilized to identify potential compounds, which were then subjected to experimental tests for their sirt2 inhibitory activity. five of the 15 tested compounds including jfd00244 displayed inhibitory activity toward sirt2, resulting in a hit ratio of 33% in a micromolar level. jfd00244 and another analog of the five compounds yielded in vitro ic(50) values of 56.7 and 74.3 microm, respectively. on the basis of these results, a phenol moiety on the active compounds including jfd00244 was suggested to be critical for sirt2 inhibitory activity. this phenol group, together with a hydrophobic moiety and hydrogen-bonding features, was thus recommended to form an active sirt2 pharmacophore [1].
IC 50
56.7 μm
references
[1] tervo aj, kyrylenko s, niskanen p, salminen a, leppnen j, nyrnen th, jrvinen t, poso a. an in silico approach to discovering novel inhibitors of human sirtuin type 2. j med chem. 2004 dec 2;47(25):6292-8.
Check Digit Verification of cas no
The CAS Registry Mumber 96969-83-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,9,6 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 96969-83:
(7*9)+(6*6)+(5*9)+(4*6)+(3*9)+(2*8)+(1*3)=214
214 % 10 = 4
So 96969-83-4 is a valid CAS Registry Number.
