96994-72-8

Upstream product

• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 6574-99-8 3,4-dichloro-benzonitrile 
• 1197-19-9 4-cyano-N,N-dimethylaniline 
• 1428637-03-9 C₁₀H₁₃ClN₂O 
• 137042-67-2 3-bromo-4-methoxybenzonitrile 

Downstream Products

• 1428637-21-1 2-chloro-N,N-dimethyl-4-(1H-tetrazol-5-yl)aniline 
• 1026565-13-8 2-(3-Chloro-4-dimethylamino-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol 

Relevant academic research and scientific papers

Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides

The special reactivity of N,N-dialkylaniline N-oxides allows practical and convenient access to electron-rich aryl halides. A complementary pair of reaction protocols allow for the selective para-bromination or ortho-chlorination of N,N-dialkylanilines in up to 69% isolated yield. The generation of a diverse array of halogenated anilines is made possible by a temporary oxidation level increase of N,N-dialkylanilines to the corresponding N,N-dialkylaniline N-oxides and the excision of the resultant weak N-O bond via treatment with thionyl bromide or thionyl chloride at low temperature.

Ruthenium-catalyzed intramolecular selective halogenation of O-methylbenzohydroximoyl halides: A new route to halogenated aromatic nitriles

The intramolecular halogenation of O-methylbenzohydroximoyl halides in the presence of a Ru catalyst and the ligand diphenylacetylene afforded halo substituted aromatic nitriles in a highly regioselective manner. Further, substituted nitriles were converted into substituted tetrazole derivatives in the presence of NaN3 and I2.

2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF

The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumo

THE REACTION OF ACTIVATED ARYL AND HETEROARYL DIHALIDES WITH HMPA. A REGIOSELECTIVITY STUDY

A series of activated aryl and heteroaryl dihalides were reacted with HMPA at elevated temperatures.Of the eleven examples studied, all but one reacted in a regioselective manner to give a monohalo-N,N-dimethylamino derivative.