97-14-3Relevant academic research and scientific papers
Reactivity of α-Amino Acids in the Reaction with Esters in Aqueous–1,4-Dioxane Media
Kochetova,Kustova,Kuritsyn
, p. 80 - 85 (2018/03/09)
The kinetics of the reaction of a series of α-amino acids with 4-nitrophenyl acetate, 4-nitrophenyl benzoate, and 2,4,6-trinitrophenyl benzoate in aqueous 1,4-dioxane medium has been studied. Kinetics of the reactions involving 4-nitrophenyl acetate and 2,4,6-trinitrophenyl benzoate has complied with the Br?nsted dependence and revealed linear correlation between rate constant logarithm and the energy difference of the frontier orbitals of α-amino acids anions.
Siloxyl ether functionalized resins for chemoselective enrichment of carboxylic acids
Trader, Darci J.,Carlson, Erin E.
supporting information; experimental part, p. 5652 - 5655 (2011/12/04)
Although the carboxylic acid moiety is prevalent in many biologically produced molecules, including natural products and proteins, methods to chemoselectively target this functional group have remained elusive. Generally, strategies that utilize carboxylate nucleophilicity also promote reactions with other nucleophiles such as amines and hydroxyls. A reagent was sought to facilitate the selective isolation of carboxylic acid containing compounds from complex mixtures. Here, the development of siloxyl ether functionalized solid supports is described.
Mechanism and Stereochemistry of the Activation of (2S)- and (2R)-Serine O-Sulfate as Suicide Inhibitors for Escherichia coli Glutamic Acid Decarboxylase
Rose, Janet E.,Leeson, Paul D.,Gani, David
, p. 3089 - 3094 (2007/10/02)
E. coli glutamic acid decarboxylase is inactivated by both enantiomers of the suicide inhibitor serine O-sulfate; inactivation by the (2S)-enantiomer involves Cα-H bond cleavage while inactivation by the (2R)-isomer involves Cα-decarboxylation.Both processes occur on the 4'-Re-face of the coenzyme, the opposite face to that utilised in physiological decarboxylation.
