97-75-6

Basic information

• Product Name: hyoscine N-oxide
• Synonyms: hyoscine N-oxide;[(1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonane 9-oxide]-7β-yl (S)-α-(hydroxymethyl)benzenacetate;Genoscopolamine;Hyoscineamine oxide;Scopolamine aminoxide;Scopolamine N-Oxide;GSYQNAMOFFWAPF-REPVILDYSA-N
• CAS NO: 97-75-6
• Molecular Formula: C₁₇H₂₁NO₅
• Molecular Weight: 319.3523
• EINECS: 202-606-2
• Mol File: 97-75-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: ~80°
• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: hyoscine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: hyoscine N-oxide(97-75-6)
• EPA Substance Registry System: hyoscine N-oxide(97-75-6)

Safety Data

• Hazardous Substances Data: 97-75-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 97-75-6 differently. You can refer to the following data:
1. Scopolamine N-Oxide is an impurity of Scopolamine (S200000), an acetylcholine antagonist used in the treatment of motion sickness and also used as antiemetic, antispasmodic, mydriatic, preanesthetic a gents.
2. Scopolamine N-Oxide is an impurity of Scopolamine (S200000), an acetylcholine antagonist used in the treatment of motion sickness and also used as antiemetic, antispasmodic, mydriatic, preanesthetic agents.

InChI:InChI=1/C17H21NO5/c1-18(21)13-7-11(8-14(18)16-15(13)23-16)22-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11?,12?,13-,14-,15-,16+,18?/m0/s1

Upstream product

• 51-34-3 scopolamine 

Relevant articles and documents

Synthesis and evaluation of enzyme inhibitory potential of some derivatives of scopolamine

This study was designed to synthesize and evaluate derivatives of scopolamine (1) as acetylcholine esterase and protease inhibitors. Scopolamine (1) was extracted from the aerial parts of Datura innoxia through bioassay guided fractionation. Five different derivatives of scopolamine (1) were synthesized, and identified through spectroscopic studies. Their acetylcholine esterase (AChE) and trypsin inhibitory potentials were determined through standard protocols and evaluated from the perspective of structure-activity relationship. The synthesized scopolamine derivatives (2-6) showed remarkable AChE inhibitory activity, except for scopoline (6). The results showed higher enzyme inhibition potential of the synthesized compounds (2-5) as compared to scopolamine (1). Maximum inhibition was exhibited by scopolamine N -oxide (89.9 ± 1.2%, IC50 = 37.4 ± 1.1 μM)), followed by scopolamine sulfonic acid (70.3 ± 0.8%, IC50 = 46.9 ± 1.0 μM) and O-methyl scopolamine (66.1 ± 1.2%, IC50 = 94.7 ± 0.8 μM). All derivatives showed moderate activity against trypsin; maximum activity was exhibited by 6 (54.0 ± 1.4%) with IC50 = 621.2 ± 3.7 μM.