97004-50-7Relevant academic research and scientific papers
Domino syntheses of five-, six- and seven-membered O-, N- and S-heterocycles from α-, β- and γ-substituted carboxylic esters
Loeffler,Schobert
, p. 2799 - 2802 (2007/10/03)
By a one-pot procedure, tetronic acids, tetronates, coumarins, benzoxepinones and their N- and S-analogues are readily accessible from keteneylidene(triphenyl)phosphorane 2 and carboxylic esters bearing OH, NHR or SH groups in an α-, β- or γ-position by an addition/Wittig olefination/(Claisen rearrangement) sequence. This cascade can be controlled by temperature variation. Extension of this procedure by a further addition step yielding annulated bisheterocycles such as the furoquinolone 28 is possible in some cases.
Cumulated Ylides, XIV - Phosphacumulene Ylides - Building Blocks for the Synthesis of Heterocyclic Compounds
Bestmann, Hans Juergen,Schmid, Guenter,Sandmeier, Dieter,Schade, Gerold,Oechsner, Helmut
, p. 1709 - 1719 (2007/10/02)
Phosphacumulene ylides 1 and acidic compounds 4 combine to give phosphoranes 5, which cyclize by an intramolecular reaction (mostly Wittig reaction) with formation of heterocycles 7.
