97006-34-3Relevant academic research and scientific papers
PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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Page/Page column 348; 349, (2020/01/11)
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
Synthesis of Stereoisomeric 3-Substituted Cyclobutanecarboxylic Acid Derivatives
Dehmlow, Eckehard V.,Schmidt, Stefan
, p. 411 - 414 (2007/10/02)
The preparation of 3-substituted cyclobutanecarboxylic acids by ring forming malonic ester cycloalkylation/saponification/decarboxylation leads to 50:50 cis/trans mixtures.Only some polar ester derivatives 2 can be separated by chromatographic methods.Catalytic hydrogenation of 3-substituted cyclobutanecarboxylic acids 3, however, gives the cis acids 4 with 90-95 percent selectivity.Reduction of the same acids 3 by Zn in aqueous HCl/THF leads to the trans acids 6 with 90-93 percent selectivity.
