97015-29-7Relevant academic research and scientific papers
Synthesis of Densely Substituted Pyridine Derivatives from 1-Methyl-1,3-(ar)enynes and Nitriles by a Formal [4+2] Cycloaddition Reaction
He, Dandan,Wang, Bowen,Duan, Kanghui,Zhou, Yang,Li, Meng,Jiang, Huanfeng,Wu, Wanqing
supporting information, p. 1292 - 1297 (2022/02/14)
An attractive method for assembling densely substituted pyridine derivatives from 1-methyl-1,3-(ar)enynes and nitriles via a formal [4+2] cycloaddition has been established. The well-balanced affinities of two alkali metal salts enable C(sp3)-H bond activation and excellent chemo- and regioselectivities. Experimental studies revealed that nitrile functions only as a partial nitrogen source for pyridine synthesis, and the addition of a metalated imine intermediate to an intramolecular alkyne is the rate-limiting step.
Rhodium(iii)-catalyzed annulation of enamides with sulfoxonium ylides toward isoquinolines
Hong, Chao,Yu, Shuling,Liu, Zhanxiang,Zhang, Yuhong
, p. 11490 - 11494 (2021/03/31)
An efficient rhodium(iii)-catalyzed C-H activation followed by intermolecular annulation between enamides and sulfoxonium ylides has been developed. The transformation proceeds smoothly with a broad range of substrates, affording a series of isoquinoline derivatives in moderate to good yields under additive-free conditions.
Facile benzannulation of isocoumarins in the efficient synthesis of diversified 1,3-disubstituted isoquinolines
Manivel,Prabakaran,Khan, F. Nawaz,Jin, Jong Sung
experimental part, p. 347 - 357 (2012/05/20)
An efficient and facile one-pot synthesis of 1,3-disubstituted isoquinolines 3 was accomplished from 3-substituted isocoumarins 1 through diketones, formed in situ via the Grignard reaction, in the presence of ammonium acetate, montmorillonite K-10 catalyst, and ethanol solvent. Springer Science+Business Media B.V. 2011.
Preparation of 1,3-disubstituted isoquinoline derivatives from N-Boc-3-substituted-1,2-dihydroisoquinolones
Clark,Jahangir
, p. 81 - 87 (2007/10/02)
3-Substituted N-Boc-1,2-dihydroisoquinolines 2 can be functionalized at the 1-position via lithiation and subsequent electrophilic trapping. The resulting products 3 can be deprotected and oxidized to afford the correspondihg 1,3-disubstituted isoquinolin
