97051-25-7

Upstream product

• 19430-32-1 2-Chloro-5-(4-nitrophenyl)-1,3,4-thiadiazole 
• 62-23-7 4-nitro-benzoic acid 
• 81188-34-3 5-(p-nitrophenyl)-2-mercapto-1,3,4-thiadiazole 
• 833-63-6 5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine 
• 207236-15-5 2-ethylsulfanyl-5-(4-nitro-phenyl)-[1,3,4]thiadiazole 

Downstream Products

• 97051-29-1 5-(4-Nitro-phenyl)-3-prop-2-ynyl-3H-[1,3,4]thiadiazol-2-one 
• 97051-12-2 5-(4-Nitro-phenyl)-3-(4-pyrrolidin-1-yl-but-2-ynyl)-3H-[1,3,4]thiadiazol-2-one 
• 97051-13-3 5-(4-Nitro-phenyl)-3-(4-piperidin-1-yl-but-2-ynyl)-3H-[1,3,4]thiadiazol-2-one; hydrochloride 
• 97051-15-5 3-(4-Azepan-1-yl-but-2-ynyl)-5-(4-nitro-phenyl)-3H-[1,3,4]thiadiazol-2-one; hydrochloride 
• 97051-14-4 3-[4-((2S,6R)-2,6-Dimethyl-piperidin-1-yl)-but-2-ynyl]-5-(4-nitro-phenyl)-3H-[1,3,4]thiadiazol-2-one; hydrochloride 
• 97051-16-6 3-[4-(4-Methyl-piperazin-1-yl)-but-2-ynyl]-5-(4-nitro-phenyl)-3H-[1,3,4]thiadiazol-2-one; hydrochloride 
• 97051-26-8 5-(4-nitrophenyl)-1,3,4-thiadiazol-2(3H)-one 

Relevant academic research and scientific papers

Synthesis and antifungal activity of 2-aryl-1,3,4-thiadiazole-5-sulphides, sulphoxides and sulphones

2-Aryl-1,3,4-thiadiazole-5-sulphides, sulphoxides and sulphones were synthesized and tested against a variety of fungal strains, Miconazole and fluconazole were used as reference drugs. The most active compounds against Candida albicans, Candida spp., Cryptococcus neoformans and Aspergillus niger were 2-(1-methyl-5-nitro-2-imidazolyl)-5-methylsulphonyl-1 ,3,4-thiadiazole (8h) and 2-(5-nitro-2-furyl)-5-methylsulphonyl-1,3,4-thiadiazole (8f). Our results showed that compounds 8h and 8f were several times more active than fluconazole in most fungal strains.