97053-11-7Relevant academic research and scientific papers
A convenient synthesis of hindered N-ARYL substituted cyclic amines
Akula, Murthy R.,Kabalka, George W.
, p. 2063 - 2070 (2007/10/03)
An efficient and high yielding synthesis of N-substituted pyrrolidines and piperidines is described.
SYNTHESIS OF STERICALLY HINDERED 1-ARYLPYRROLIDINES AND 1-ARYLPIPERIDINES BY CONDENSATION OF PRIMARY AROMATIC AMINES WITH CYCLIC ETHERS OR DIOLS
Walkup, Robert E.,Searles, Scott
, p. 101 - 106 (2007/10/02)
A variety of 1-(o-alkylphenyl)- and 1-(o-o'-dialkylphenyl)-pyrrolidines and -piperidines were prepared by the gas phase alumina mediated condensation of tetrahydrofuran (THF), tetrahydropyran (THP) or the corresponding diols with primary aromatic amines in fair to high yield.This methodology can also be used for the synthesis of 1-phenylhexahydroazepine from aniline.A mechanistic interpretation of the catalytic action of alumina is presented.
