97053-36-6Relevant academic research and scientific papers
Facile Synthesis of Fluorine Containing Imidazopyridines, Pyrazoloimidazoles and 2-Iminoarylazothiazoles through &α-Oxo-N-aryl-&α-arylethanehydrazonoyl Bromides
Joshi, Krishna C.,Pathak, Vijai N.,Sharma, Sharda
, p. 124 - 128 (2007/10/02)
α-Oxo-N-aryl-α-arylethanehydrazonoyl bromides (I) react with 5-amino-3-arylpyrazole in ethanol to form 2,6-diaryl-3-arylazo-1H-pyrazoloimidazoles (II) in quantitative yields.Treatment of I with 2-aminopyridine and 1-p-ethoyphenyl-2-thiourea affords 2-aryl-3-arylazoimidazopyridines (III) and 4-aryl-5-arylazo-2-iminothiazoles (IV) in 70 - 80 and 60 - 70percent yields, respectively.Compound IIb (X=Z=4-F; R=Y=H) has been subjected to acetylation and Mannich reaction.All the compounds have been characterized by their analytical and spectral (IR, PMR and mass) data.Representative compounds have been screened for their antiimplantation activity in adult female rats at 20 mg/kg dose.
