97063-30-4

Upstream product

• 92433-16-4 ω-Azido-ω-(4-methoxy-phenylmercapto)-4-brom-acetophenon 
• 586-75-4 4-chlorobenzoyl chloride 
• 696-63-9 4-Methoxybenzenethiol 
• 5798-76-5 phenyl 4-bromobenzoate 
• 100865-23-4 2-bromo-1-(4-bromo-phenyl)-2-(4-methoxy-phenylsulfanyl)-ethanone 

Relevant academic research and scientific papers

Conversion of esters to thioesters under mild conditions

We report conversion of esters to thioestersviaselective C-O bond cleavage/weak C-S bond formation under transition-metal-free conditions. The method is notable for a general and practical transition-metal-free system, broad substrate scope and excellent functional group tolerance. The strategy was successfully deployed in late-stage thioesterification, site-selective cross-coupling/thioesterification/decarbonylation and easy-to-handle gram scale thioesterification. Selectivity and computational studies were performed to gain insight into the formation of weak C-S bonds by C-O bond cleavage, which contrasts with the traditional trend of nucleophilic additions to carboxylic acid derivatives.