97097-56-8Relevant academic research and scientific papers
SYNTHESIS OF STABLE ANALOGUES OF TXA2
Evans, Elizabeth H.,Hewson, Alan T.,March, Lorraine A.,Nowell, Ian W.,Wadsworth, Alan H.
, p. 137 - 150 (2007/10/02)
Intramolecular aldol condensations and intramolecular Lewis acid-catalysed alkylations are used in approaches to substituted bicyclononanes and bicyclooctanes, specifically the oxo esters ( 7 ), ( 8 ), and ( 9 ).A ring expansion to a cycloheptane derivative is observed on treatment of the cyclopentyl derivative ( 18 ) with acid, and the bicyclodecane and bicyclononane derivatives ( 34 ) and ( 36 ) are obtained from the prenyl derivatives ( 30 ) and ( 35 ) respectively.The oxo esters ( 7 ), (8 ), and ( 9 ) are converted into the stable TXA2 analogues ( 10 ), ( 11 ), and ( 12 ) respectively, by a series of reactions which involve stereospecific functionalisation of their ketone and ester groups.
INTRAMOLECULAR LEWIS ACID CATALYSED ALKYLATIONS
Evans, Elizabeth H.,Hewson, Alan T.,Hadsworth, Alan H.
, p. 243 - 248 (2007/10/02)
Lewis acid catalysed cyclisations of enol derivatives leading to both bridged and fused bicyclic systems are described.
