97172-94-6Relevant academic research and scientific papers
Oxidation of oximes to nitrile oxides with hypervalent iodine reagents
Mendelsohn, Brian A.,Lee, Shelley,Kim, Simon,Teyssier, Florian,Aulakh, Virender S.,Ciufolini, Marco A.
supporting information; experimental part, p. 1539 - 1542 (2009/08/07)
Iodobenzene diacetate in MeOH containing a catalytic amount of TFA efficiently oxidizes aldoximes to nitrile oxides. The latter may be trapped in situ with olefins in a bimolecular or an intramolecular mode. The new method enables the execution of tandem oxidative dearomatization of phenols/intramolecular nitrile oxide cycloaddition sequences leading to useful synthetic intermediates.
