97186-53-3Relevant academic research and scientific papers
Stereoselective synthesis of imidazolidin-2-ones via Pd-catalyzed alkene carboamination. Scope and limitations
Fritz, Jonathan A.,Wolfe, John P.
, p. 6838 - 6852 (2008/09/21)
A method for the synthesis of imidazolidin-2-ones from N-allylureas and aryl or alkenyl bromides via Pd-catalyzed carboamination reactions is described. The N-allylurea precursors are prepared in one step from readily available allylic amines and isocyanates, and the Pd-catalyzed reactions effect the formation of a C-C bond, a C-N bond, and up to two stereocenters in a single step. Good diastereoselectivities are obtained for the conversion of substrates bearing allylic substituents to 4,5-disubstituted imidazolidin-2-ones, and excellent selectivity for the generation of products resulting from syn-addition across the alkene is observed when substrates derived from cyclic alkenes or E-1,2-disubstituted alkenes are employed. A brief discussion of reaction mechanism and product stereochemistry is presented.
A simple access to trichloroacetimidates
Patil, Vijay J.
, p. 1481 - 1484 (2007/10/03)
O - Trichloroacetimidates can be prepared, under mild conditions in high yield and high purity, by reacting the substrate with trichloroacetonitrile in dichloromethane and 50% aqueous potassium hydroxide mixture containing a catalytic amount of tetra-n-butylammonium hydrogen sulfate.
A New Approach to (+/-)-2-Amino-2-deoxytetritol Derivatives
Bongini, Alessandro,Cardillo, Giuliana,Orena, Mario,Sandri, Sergio,Tomasini, Claudia
, p. 935 - 940 (2007/10/02)
A new approach to the (+/-)-2-amino-2-deoxytetritol derivatives (1), (2) and (3) is described, starting either from the allylic trichloroacetimidate (5) or from the allylic trichloroacetamidate (11).The 4,5-dihydro-oxazole (6), obtained by iodocyclization
