97186-54-4Relevant academic research and scientific papers
Catalytic asymmetric synthesis of allylic aryl ethers
Kirsch, Stefan F.,Overman, Larry E.,White, Nicole S.
, p. 911 - 913 (2007/10/03)
(Chemical Equation Presented) The reaction of trichloroacetimidate derivatives of (Z)-2-alken-1-ols with phenol nucleophiles in the presence of the palladium(II) catalyst [COP-OAc]2 provides 3-aryloxy-1-alkenes in high yields and high enantiomeric purity (typically 63-90% yield and 90-97% ee). The reaction is exemplified by 20 examples. The method employs 1 mol % of the commercially available catalysts (S)- or (R)-[COPOAc]2, produces the branched isomer with unprecedented regioselectivity, and is compatible with the presence of base-labile functionality in either reactant.
