97187-25-2Relevant academic research and scientific papers
Synthesis of 5'--5'-deoxyadenosine
Kolb, Michael,Barth, Jacqueline
, p. 1036 - 1040 (2007/10/02)
The synthesis of the title compound 2 is described.N-Alkylation of 5'-amino-5'-deoxy-2',3'-O-(1-methylethylidene)adenosine (3) with benzene gave after debenzylation the 5'-deoxyadenosine derivative 4b.After derivatization of the 5'-NH, the terminal hydroxy group was reacted with triphenylphosphane, diethyl azodicarboxylate, and N-hydroxyphthalimide to yield a full protected derivative of 2.Sequential deprotection (H2NNH2, then H2SO4) afforded the target molecule 2 as its sesquisulfate salt.
