972-05-4

Upstream product

• 3923-52-2 1,1-diphenyl-2-propyn-1-ol 
• 972-07-6 4-morpholin-4-yl-1,1-diphenyl-but-2-yn-1-ol 
• 3848-49-5 1,1-diphenyl-2-propyn-1-yl acetate 
• 110-91-8 morpholine 
• 201230-82-2 carbon monoxide 
• 3923-51-1 1,1-diphenylprop-2-en-1-ol 

Relevant academic research and scientific papers

Regioselective hydroaminomethylation of 1,1-diaryl-allyl-alcohols: A new access to 4,4-diarylbutylamines

Pharmacologically active 4,4-diarylbutylamines like Fluspirilene and 4-amino-1,1-diarylbutan-1-ols like Difenidol were prepared in high yields via rhodium catalysed hydroaminomethylation of 1,1-diaryl-allylalcohols. Conversion of these olefins with carbon monoxide, hydrogen and secondary amines proceeds with complete regioselectivity. This group can easily be removed under acidic and hydrogenating conditions, enabling the transformation of 4-amino-1,1-diarylbutan-1-ols to 4,4-diarylbutylamines in high yields. Thus Fluspirilene was synthesised in 88% yield in four steps starting from commercially available materials. Graphical Abstract.